This National Institutes of Health grant is designed to promote the discovery of cellular and molecular mechanisms underlying brain blood vessel responses to anti-beta-amyloid immunotherapy, which can lead to Amyloid Related Imaging Abnormalities (ARIA). This grant is for establishing a comprehensive understanding of these molecular processes. The ultimate purpose is to identify and validate novel molecular targets capable of protecting the blood-brain barrier (BBB) and brain blood vessels during therapeutic interventions that address beta-amyloid, thereby enhancing treatment safety and efficacy.
Opportunity ID: 353483
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-198 |
| Funding Opportunity Title: | Protective Strategies to Reduce Amyloid Related Imaging Abnormalities (ARIA) After Anti-Amyloid Beta Immunotherapy (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 10, 2024 |
| Last Updated Date: | Apr 10, 2024 |
| Original Closing Date for Applications: | Nov 05, 2024 |
| Current Closing Date for Applications: | Nov 05, 2024 |
| Archive Date: | Dec 11, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) For profit organizations other than small businesses Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-198.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 353483 Full Announcement-PAR-24-198 -> PAR-24-198-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00285809 | Sep 04, 2024 | Nov 05, 2024 | View |
Package 1
Mandatory forms
353483 RR_SF424_5_0-5.0.pdf
353483 PHS398_CoverPageSupplement_5_0-5.0.pdf
353483 RR_OtherProjectInfo_1_4-1.4.pdf
353483 PerformanceSite_4_0-4.0.pdf
353483 RR_KeyPersonExpanded_4_0-4.0.pdf
353483 PHS398_ResearchPlan_5_0-5.0.pdf
353483 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353483 RR_Budget_3_0-3.0.pdf
353483 RR_SubawardBudget30_3_0-3.0.pdf
353483 PHS398_ModularBudget_1_2-1.2.pdf
353483 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
