This National Institutes of Health (NIH) grant is for investigating aging’s impact on osteoimmunology, the crucial bidirectional interactions between bone and the immune system. It supports studies on normal and pathobiological changes in aging bone marrow affecting immune function. Differing from prior young-animal research, this grant prioritizes studies comparing older (18+ months) to young adult (4+ months) mice. The objective is to understand how age influences healthy and maladaptive changes within the marrow niche, including bone loss, myeloid skewing, and declining immune function, and their impact on health trajectories.
Opportunity ID: 330304
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-22-002 |
| Funding Opportunity Title: | Aging Effects on Osteoimmunology (R01 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2020 |
| Last Updated Date: | Dec 10, 2020 |
| Original Closing Date for Applications: | Jun 15, 2021 |
| Current Closing Date for Applications: | Jun 15, 2021 |
| Archive Date: | Jul 21, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts State governments City or township governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA seeks to support studies on normal and pathobiological changes in aging bone marrow that impact, or are impacted by, changes in immune function with age. Studies to be supported are in the field of osteoimmunology, which concerns the bidirectional interactions between bone and the immune system. The importance of osteoimmunology and its potential for improving the understanding of bone homeostasis is now recognized. However, most research has been conducted in young mice (3-4 months) that have not completed growth and development. Young animals cannot exhibit the relevant age-associated changes in immune function in the marrow niche that can best be revealed by comparison of older mice (at or older than 18 months) to young adult mice (at least 4 months of age). While important insights have been gained about osteoimmunological signaling pathways in the bone marrow niche of young adults, this approach has not addressed important questions more directly focused on age-related bone loss and the myriad of complex tissue interactions one expects, since bone is an endocrine organ. Pathobiological changes that occur in the aging marrow niche, such as myeloid skewing and declining immune function, are well-documented in the field of immunology. In addition, the role of T cells in osteoclast differentiation, bone resorption, and bone turnover have been demonstrated. However, many questions remain regarding how and why these changes occur over time in both healthy adults and older adults where bone loss is more commonly a major concern. The effect of age on healthy (adaptive) and pathobiological (maladaptive) changes that occur in the aging marrow niche and how these changes affect health trajectories in age-appropriate laboratory animals are the focus of this FOA. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-22-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00264434 | May 15, 2021 | Jun 15, 2021 | View |
Package 1
Mandatory forms
330304 RR_SF424_2_0-2.0.pdf
330304 PHS398_CoverPageSupplement_5_0-5.0.pdf
330304 RR_OtherProjectInfo_1_4-1.4.pdf
330304 PerformanceSite_2_0-2.0.pdf
330304 RR_KeyPersonExpanded_2_0-2.0.pdf
330304 PHS398_ResearchPlan_4_0-4.0.pdf
330304 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
330304 RR_Budget_1_4-1.4.pdf
330304 RR_SubawardBudget30_1_4-1.4.pdf
330304 PHS398_ModularBudget_1_2-1.2.pdf
330304 PHS_AssignmentRequestForm_3_0-3.0.pdf
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