This grant from the National Institutes of Health (NIH) is for the purpose of establishing a comprehensive cardiovascular (CV) tissue biorepository and an associated infrastructure. This initiative aims to advance discovery and mechanistic research into CV complications specific to Type 1 Diabetes (T1D), addressing the critical lack of T1D-specific therapies despite CVD being the leading cause of death for individuals with T1D. The grant will support a two-phase research plan: first, to collect, store, and distribute human cadaveric CV tissues from donors with T1D, T2D, and without diabetes, ensuring quality control. Second, it will establish a Data Coordinating Center for a consortium to perform multimodal analysis, deeply phenotyping tissues and making results available in a public data portal to facilitate new insights.
Opportunity ID: 335114
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-21-010 |
| Funding Opportunity Title: | Cardiovascular Biorepository for Type 1 Diabetes (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.837 — Cardiovascular Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 04, 2021 |
| Last Updated Date: | Aug 04, 2021 |
| Original Closing Date for Applications: | Oct 20, 2021 |
| Current Closing Date for Applications: | Oct 20, 2021 |
| Archive Date: | Nov 25, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses County governments Independent school districts Special district governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites a single cooperative agreement application to establish a biorepository of human cardiovascular (CV) tissue and an infrastructure for discovery and mechanistic research to increase our knowledge of the CV complications of type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of death and morbidity for individuals with T1D, but no T1D-specific therapy exists to prevent or treat this complication of diabetes because of challenges from inadequate preclinical models, decades-long disease progression and poorly defined differences in pathogenesis compared to type 2 diabetes (T2D). The FOA will support a two-phase research plan to encourage the use of human CV tissue to overcome these challenges. The goal of the first phase is to establish a biorepository through 1) the collection and storage of human cadaveric tissues from donors with T1D, T2D, and without diabetes; 2) the performance of quality control and basic histopathologic examination; and 3) the creation of a process for distribution of the biosamples and data to qualified investigators. The goal of the second phase is to serve as the Data Coordinating Center for a consortium that will perform a multimodal analysis to deeply phenotype the anatomical, cellular, and molecular composition of the tissues and make the results available in a public data portal. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-21-010.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268426 | Sep 20, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335114 RR_SF424_2_0-2.0.pdf
335114 PHS398_CoverPageSupplement_5_0-5.0.pdf
335114 RR_OtherProjectInfo_1_4-1.4.pdf
335114 PerformanceSite_2_0-2.0.pdf
335114 RR_KeyPersonExpanded_2_0-2.0.pdf
335114 RR_Budget_1_4-1.4.pdf
335114 PHS398_ResearchPlan_4_0-4.0.pdf
335114 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335114 RR_SubawardBudget30_1_4-1.4.pdf
335114 PHS_AssignmentRequestForm_3_0-3.0.pdf
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