This NCATS grant facilitates translational and clinical research, fostering collaborations between NCATS intramural scientists and the extramural community. Its purpose is to discover and develop new chemistries for previously undrugged biological targets across various human diseases. The grant leverages NCATS’ integrated ASPIRE platform, combining automated synthetic chemistry, AI/ML, engineering, informatics, and biological testing. Funding supports collaborations to enhance this platform through new physical modules. Expected outcomes include identifying, designing, synthesizing, and validating novel chemical entities as drug development starting points, expanding the chemical space for drug screening.
Opportunity ID: 330317
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-21-001 |
| Funding Opportunity Title: | New Chemistries for Un-drugged Targets through A Specialized Platform for Innovative Research Exploration (ASPIRE) Collaborative Research Program (UG3/UH3 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2020 |
| Last Updated Date: | Dec 10, 2020 |
| Original Closing Date for Applications: | Jul 08, 2021 |
| Current Closing Date for Applications: | Jul 08, 2021 |
| Archive Date: | Aug 13, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education For profit organizations other than small businesses County governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Private institutions of higher education State governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of the ASPIRE Collaborative Research Program is to facilitate translational and clinical research between NCATS intramural scientists and the extramural community to develop approaches that will enhance the ability to discover and develop new chemistries towards previously undrugged biological targets (i.e., biological targets with no known drugs to modulate their function) across many human diseases and conditions. NCATS intramural scientists have established an integrated NCATS ASPIRE platform consisting of physical and virtual modules for automated synthetic chemistry, artificial intelligence (AI) and machine learning (ML), engineering, informatics, and biological testing. The FOA will support intramural – extramural collaborations to develop additional physical modules that will enhance the platforms capabilities. The anticipated outcome includes identification, design, synthesis, and validation of new chemical entities as starting points for drug development of novel targets, and the expansion of chemical space available for drug screening. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-21-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00264422 | Jun 08, 2021 | Jul 08, 2021 | View |
Package 1
Mandatory forms
330317 RR_SF424_2_0-2.0.pdf
330317 PHS398_CoverPageSupplement_5_0-5.0.pdf
330317 RR_OtherProjectInfo_1_4-1.4.pdf
330317 PerformanceSite_2_0-2.0.pdf
330317 RR_KeyPersonExpanded_2_0-2.0.pdf
330317 RR_Budget_1_4-1.4.pdf
330317 PHS398_ResearchPlan_4_0-4.0.pdf
330317 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
330317 RR_SubawardBudget30_1_4-1.4.pdf
330317 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
