The National Cancer Institute (NCI) and National Institute on Aging (NIA) are offering this grant to advance the understanding of how aging influences cancer initiation and development. This funding opportunity encourages research into the mechanistic factors and cellular interactions that drive cancer-initiating cell formation during the aging process. Specifically, the grant aims to explore how hallmarks of aging, such as metabolic alterations, proteostasis, epigenetic changes, and impaired DNA repair, contribute to cancer development. Furthermore, it seeks to investigate the role of alterations in the microenvironment, including inflammation and immunosenescence, in the outgrowth of cancer-initiating cells. Collaborative applications between scientists in aging biology and cancer biology are strongly encouraged.
Opportunity ID: 328000
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-20-040 |
| Funding Opportunity Title: | Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.396 — Cancer Biology Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 02, 2020 |
| Last Updated Date: | Jul 02, 2020 |
| Original Closing Date for Applications: | Feb 17, 2021 |
| Current Closing Date for Applications: | Feb 17, 2021 |
| Archive Date: | Mar 25, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Small businesses State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) and National Institute on Aging (NIA) will promote research to advance the understanding of the mechanistic factors and cellular interactions during aging that contributes to cancer initiation. Collaborations are strongly encouraged between scientists in the fields of aging biology and cancer biology. Applications should address key questions regarding how hallmarks of aging that lead to impaired cellular activities (metabolic alterations, proteostasis, epigenetic changes, and DNA repair) and alterations in the microenvironment (inflammation and immunosenescence) contribute to the development and outgrowth of cancer-initiating cells. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-20-040.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262445 | Sep 27, 2020 | Feb 17, 2021 | View |
Package 1
Mandatory forms
328000 RR_SF424_2_0-2.0.pdf
328000 PHS398_CoverPageSupplement_5_0-5.0.pdf
328000 RR_OtherProjectInfo_1_4-1.4.pdf
328000 PerformanceSite_2_0-2.0.pdf
328000 RR_KeyPersonExpanded_2_0-2.0.pdf
328000 PHS398_ResearchPlan_4_0-4.0.pdf
328000 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328000 RR_Budget_1_4-1.4.pdf
328000 RR_SubawardBudget30_1_4-1.4.pdf
328000 PHS398_ModularBudget_1_2-1.2.pdf
328000 PHS_AssignmentRequestForm_3_0-3.0.pdf
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