This NIAAA R01 grant is for investigating molecular and cellular mechanisms of alcohol-induced tissue injury and repair. Excessive alcohol consumption harms multiple organ systems (e.g., liver, brain, heart) and reduces post-trauma recovery capacity; these mechanisms are poorly understood. NIAAA encourages integrative research to elucidate alcohol’s effects on complex injury/repair processes, common or specific to various organ systems. Studies on alcohol’s impact on stem cells, embryonic development, regeneration, and moderate alcohol’s cellular actions are also encouraged. This research aims to inform new prognosis, diagnosis, intervention, and treatment strategies for alcohol-induced organ damage.
Opportunity ID: 294103
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-17-297 |
| Funding Opportunity Title: | Alcohol-Induced Effects on Tissue Injury and Repair (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 25, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2020 |
| Current Closing Date for Applications: | Sep 07, 2020 |
| Archive Date: | Oct 13, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Special district governments Private institutions of higher education City or township governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages Research Project Grant (R01) applications to study molecular and cellular mechanisms of tissue injury and repair associated with alcohol use in humans. Excessive alcohol consumption has the potential to adversely affect multiple organ systems including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle. In addition, there is accumulating evidence that long term alcohol consumption is associated with reduced host capacity for recovery and repair following trauma. The mechanisms for these alcohol-induced effects on tissue injury and repair are currently not fully understood. NIAAA is especially interested in integrative research that elucidates alcohols effects on complex mechanisms of injury and repair that are either common or specific to each organ system. This FOA also encourages the study of alcohols effect on stem cells, embryonic development, and regeneration. Also encourages are studies on molecular and cellular actions of moderate alcohol consumption. A better understanding of these underlying mechanisms may provide new avenues for developing more effective and novel approaches for prognosis, diagnosis, intervention, and treatment of alcohol-induced organ damage. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-17-297.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or before January 24, 2018 | PKG00232749 | Sep 05, 2017 | Jan 24, 2018 | View | |
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00235993 | Nov 09, 2017 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00259220 | Sep 05, 2017 | Sep 07, 2020 | View |
Package 1
Mandatory forms
294103 RR_SF424_2_0-2.0.pdf
294103 PHS398_CoverPageSupplement_3_0-3.0.pdf
294103 RR_OtherProjectInfo_1_3-1.3.pdf
294103 PerformanceSite_2_0-2.0.pdf
294103 RR_KeyPersonExpanded_2_0-2.0.pdf
294103 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
294103 RR_Budget_1_3-1.3.pdf
294103 RR_SubawardBudget30_1_3-1.3.pdf
294103 PHS398_ModularBudget_1_2-1.2.pdf
294103 PHS_Inclusion_Enrollment_Report-1.0.pdf
294103 PHS_AssignmentRequestForm-1.0.pdf
Package 2
Mandatory forms
294103 RR_SF424_2_0-2.0.pdf
294103 PHS398_CoverPageSupplement_4_0-4.0.pdf
294103 RR_OtherProjectInfo_1_4-1.4.pdf
294103 PerformanceSite_2_0-2.0.pdf
294103 RR_KeyPersonExpanded_2_0-2.0.pdf
294103 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
294103 RR_Budget_1_4-1.4.pdf
294103 RR_SubawardBudget30_1_4-1.4.pdf
294103 PHS398_ModularBudget_1_2-1.2.pdf
294103 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 3
Mandatory forms
294103 RR_SF424_2_0-2.0.pdf
294103 PHS398_CoverPageSupplement_5_0-5.0.pdf
294103 RR_OtherProjectInfo_1_4-1.4.pdf
294103 PerformanceSite_2_0-2.0.pdf
294103 RR_KeyPersonExpanded_2_0-2.0.pdf
294103 PHS398_ResearchPlan_4_0-4.0.pdf
294103 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
294103 RR_Budget_1_4-1.4.pdf
294103 RR_SubawardBudget30_1_4-1.4.pdf
294103 PHS398_ModularBudget_1_2-1.2.pdf
294103 PHS_AssignmentRequestForm_3_0-3.0.pdf
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