This grant is for establishing the Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). The IBDGC seeks to define IBD’s genetic architecture, particularly in under-represented populations, and clarify how variants impact pathophysiology and outcomes, aiming to improve prediction and treatment. The DCC will coordinate collaboration among Genetic Research Centers, manage subject enrollment, oversee biological sample and data submission, and perform data analysis. It will also manage IBDGC committees and facilitate collaboration with international partners and external investigators.
Opportunity ID: 335535
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-21-502 |
| Funding Opportunity Title: | Limited Competition for the Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 02, 2021 |
| Last Updated Date: | Sep 02, 2021 |
| Original Closing Date for Applications: | Dec 21, 2021 |
| Current Closing Date for Applications: | Dec 21, 2021 |
| Archive Date: | Jan 26, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: See Funding Announcement for Eligibility Details Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July 2002 for the purpose of identifying genetic variation predisposing to Inflammatory Bowel Disease (IBD). Since its establishment and in collaboration with the International IBD Genetics Consortium, the NIDDK IBDGC has identified over 250 IBD susceptibility loci. However, for the great majority of these loci, the specific causal variants and effector genes have not yet been identified, and the biological mechanisms through which these variants influence IBD pathophysiology remain to be elucidated. The purpose of this FOA is to renew the IBDGC with a continued mission to characterize the genetic architecture of IBD and its sub-phenotypes, particularly in populations currently under-represented in IBD genomic studies, and to elucidate the biological mechanisms by which genetic variants influence IBD pathophysiology, phenotypes and outcomes, with the long-term goal of improving disease course prediction and treatment. The Data Coordinating Center (DCC) of the IBDGC will coordinate collaboration among the Genetic Research Centers (GRCs, described in the companion FOA RFA-DK-21-022), enrollment of subjects into the study, submission of DNA and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and isolation of other components, submission of clinical, genetic and molecular data to central databases, and data analysis. The DCC will manage the operations of the IBDGC Steering Committee and other operational committees and coordinate the collaboration of the NIDDK IBDGC with the International IBDGC, and with other external investigators conducting ancillary studies. The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the IBDGC and external collaborators. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-21-502.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268768 | Nov 21, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269629 | Nov 21, 2021 | Dec 21, 2021 | View |
Package 1
Mandatory forms
335535 RR_SF424_2_0-2.0.pdf
335535 PHS398_CoverPageSupplement_5_0-5.0.pdf
335535 RR_OtherProjectInfo_1_4-1.4.pdf
335535 PerformanceSite_2_0-2.0.pdf
335535 RR_KeyPersonExpanded_2_0-2.0.pdf
335535 RR_Budget_1_4-1.4.pdf
335535 PHS398_ResearchPlan_4_0-4.0.pdf
335535 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335535 RR_SubawardBudget30_1_4-1.4.pdf
335535 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
335535 RR_SF424_5_0-5.0.pdf
335535 PHS398_CoverPageSupplement_5_0-5.0.pdf
335535 RR_OtherProjectInfo_1_4-1.4.pdf
335535 PerformanceSite_4_0-4.0.pdf
335535 RR_KeyPersonExpanded_4_0-4.0.pdf
335535 RR_Budget_3_0-3.0.pdf
335535 PHS398_ResearchPlan_4_0-4.0.pdf
335535 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
335535 RR_SubawardBudget30_3_0-3.0.pdf
335535 PHS_AssignmentRequestForm_3_0-3.0.pdf
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