This grant is for the purpose of fostering groundbreaking exploratory and developmental research in biomedical, behavioral, or clinical fields. It specifically targets the early and conceptual stages of projects that may involve considerable risk but hold potential for significant breakthroughs. The NIH Exploratory/Developmental Research Project Grant aims to support the development of novel techniques, agents, methodologies, models, or applications that could yield a major impact on a scientific area. It encourages innovative proposals that could fundamentally advance their respective fields.
Opportunity ID: 357807
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-25-304 |
| Funding Opportunity Title: | NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Jun 26, 2025 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Small businesses Public and State controlled institutions of higher education City or township governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PA-25-304.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Add ALN per NOT-MD-25-010. | Jun 26, 2025 | |
| Dec 18, 2024 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-25-304 |
| Funding Opportunity Title: | NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Jun 26, 2025 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Small businesses Public and State controlled institutions of higher education City or township governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PA-25-304.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-25-304 |
| Funding Opportunity Title: | NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Dec 18, 2024 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Special district governments City or township governments Private institutions of higher education County governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PA-25-304.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 357807 Full Announcement-PA-25-304 -> PA-25-304-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289730 | Jan 16, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357807 RR_SF424_5_0-5.0.pdf
357807 PHS398_CoverPageSupplement_5_0-5.0.pdf
357807 RR_OtherProjectInfo_1_4-1.4.pdf
357807 PerformanceSite_4_0-4.0.pdf
357807 RR_KeyPersonExpanded_4_0-4.0.pdf
357807 PHS398_ResearchPlan_5_0-5.0.pdf
357807 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357807 RR_Budget_3_0-3.0.pdf
357807 RR_SubawardBudget30_3_0-3.0.pdf
357807 PHS398_ModularBudget_1_2-1.2.pdf
357807 PHS_AssignmentRequestForm_4_0-4.0.pdf
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