This NIH grant aims to fund research exploring the mechanistic role of astrocytes in the degeneration of the neurovascular unit, particularly concerning Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRDs). Astrocytes are critical components of the neurovascular unit, influencing the blood-brain barrier and neuronal health, making them potential therapeutic targets. Despite their known roles, their precise contribution to neurodegeneration, including vascular contributions to cognitive impairment and dementia (VCID) and across various AD/ADRD diagnoses, remains largely unknown. This represents a significant gap in current understanding. This initiative is the first targeted effort by the NIH to investigate the fundamental role of astrocytes in AD/ADRD.
Opportunity ID: 335975
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-037 |
| Funding Opportunity Title: | Role of Astrocytes in Degeneration of the Neurovascular Unit in AD/ADRDs (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 30, 2021 |
| Last Updated Date: | Sep 30, 2021 |
| Original Closing Date for Applications: | Feb 04, 2022 |
| Current Closing Date for Applications: | Feb 04, 2022 |
| Archive Date: | Mar 12, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments City or township governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The neurovascular unit involves multiple pathways that contribute to neurodegeneration. Astrocytes, due to their overlapping roles regulating the blood brain barrier, neuronal health and response to degenerating cells, are uniquely positioned to be therapeutic targets. Astrocytes are a fundamental component of the neurovascular unit and are known to play a role in regulating the blood brain barrier and APOE signaling. However, the mechanistic role of astrocytes for the neurovascular unit in health and disease, including in vascular contributions to cognitive impairment and dementia (VCID) and across the spectrum of AD/ADRD diagnoses, is largely unknown, and represents a gap area and an opportunity for research investment. This initiative would represent the first targeted initiative on the fundamental role of astrocytes in AD/ADRD at the NIH. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-037.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 335975 Full Announcement-PAR-22-037 -> PAR-22-037-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269847 | Jan 04, 2022 | Feb 04, 2022 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269163 | Jan 04, 2022 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335975 RR_SF424_5_0-5.0.pdf
335975 PHS398_CoverPageSupplement_5_0-5.0.pdf
335975 RR_OtherProjectInfo_1_4-1.4.pdf
335975 PerformanceSite_4_0-4.0.pdf
335975 RR_KeyPersonExpanded_4_0-4.0.pdf
335975 PHS398_ResearchPlan_4_0-4.0.pdf
335975 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
335975 RR_Budget_3_0-3.0.pdf
335975 RR_SubawardBudget30_3_0-3.0.pdf
335975 PHS398_ModularBudget_1_2-1.2.pdf
335975 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
335975 RR_SF424_2_0-2.0.pdf
335975 PHS398_CoverPageSupplement_5_0-5.0.pdf
335975 RR_OtherProjectInfo_1_4-1.4.pdf
335975 PerformanceSite_2_0-2.0.pdf
335975 RR_KeyPersonExpanded_2_0-2.0.pdf
335975 PHS398_ResearchPlan_4_0-4.0.pdf
335975 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335975 RR_Budget_1_4-1.4.pdf
335975 RR_SubawardBudget30_1_4-1.4.pdf
335975 PHS398_ModularBudget_1_2-1.2.pdf
335975 PHS_AssignmentRequestForm_3_0-3.0.pdf
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