This grant is for investigators to conduct in-depth phenotyping and research on embryonic or perinatal lethal/subviable knockout mouse strains. These strains are being generated by the International Mouse Phenotyping Consortium (IMPC), which includes the NIH Knockout Mouse Phenotyping Program (KOMP2). The IMPC’s overarching mission is to build a comprehensive catalog of mammalian gene function, crucial for understanding human genetic variation. While the IMPC aims to phenotype every mouse gene, approximately 30% of their generated strains are expected to be lethal or subviable. This funding offers a unique opportunity to leverage these valuable mouse models, even those with viable heterozygous phenotypes, for specialized, additional phenotyping and research while they are being produced and characterized by the IMPC, advancing our understanding of gene function.
Opportunity ID: 357009
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-140 |
| Funding Opportunity Title: | In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Jan 07, 2026 |
| Current Closing Date for Applications: | Jan 07, 2026 |
| Archive Date: | Feb 12, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall, the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-140.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357009 Full Announcement-PAR-25-140 -> PAR-25-140-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288548 | May 05, 2025 | Jan 07, 2026 | View |
Package 1
Mandatory forms
357009 RR_SF424_5_0-5.0.pdf
357009 PHS398_CoverPageSupplement_5_0-5.0.pdf
357009 RR_OtherProjectInfo_1_4-1.4.pdf
357009 PerformanceSite_4_0-4.0.pdf
357009 RR_KeyPersonExpanded_4_0-4.0.pdf
357009 PHS398_ResearchPlan_5_0-5.0.pdf
357009 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357009 RR_Budget_3_0-3.0.pdf
357009 RR_SubawardBudget30_3_0-3.0.pdf
357009 PHS398_ModularBudget_1_2-1.2.pdf
357009 PHS_AssignmentRequestForm_4_0-4.0.pdf
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