This NIH grant is for supporting investigations into the cellular and molecular mechanisms by which interactions between multiple co-pathologies drive worsening neurodegenerative processes and phenotypic outcomes in dementias. Applicants must propose studies involving a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, vascular), with optional inclusion of risk factors and co-morbidities. The research should examine these co-pathology interactions across brain regions, over time, and within proximate cell populations, analyzing various intracellular dynamics and localization. The ultimate purpose is to determine what upstream and downstream events, relative to aggregated protein states, lead to worse phenotypic outcomes in multi-etiology dementias.
Opportunity ID: 348313
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-211 |
| Funding Opportunity Title: | Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 23, 2023 |
| Last Updated Date: | May 23, 2023 |
| Original Closing Date for Applications: | Oct 04, 2023 |
| Current Closing Date for Applications: | Oct 04, 2023 |
| Archive Date: | Nov 09, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses County governments State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream and downstream from aggregated protein states to determine what events lead to worse phenotypic outcomes. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-211.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 348313 Full Announcement-PAR-23-211 -> PAR-23-211-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00281830 | Sep 04, 2023 | Oct 04, 2023 | View |
Package 1
Mandatory forms
348313 RR_SF424_5_0-5.0.pdf
348313 PHS398_CoverPageSupplement_5_0-5.0.pdf
348313 RR_OtherProjectInfo_1_4-1.4.pdf
348313 PerformanceSite_4_0-4.0.pdf
348313 RR_KeyPersonExpanded_4_0-4.0.pdf
348313 PHS398_ResearchPlan_5_0-5.0.pdf
348313 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
348313 RR_Budget_3_0-3.0.pdf
348313 RR_SubawardBudget30_3_0-3.0.pdf
348313 PHS398_ModularBudget_1_2-1.2.pdf
348313 PHS_AssignmentRequestForm_3_0-3.0.pdf
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