This grant, part of the Gabriella Miller Kids First Pediatric Research Program, invites applications for whole genome sequencing of pediatric cohorts. The NIH is offering this opportunity to elucidate the genetic basis of childhood cancers and structural birth defects, and to explore the molecular links between birth defects and cancer risk. Proposals are encouraged for sequencing existing cohorts, including underrepresented racial and ethnic groups, to expand the Kids First Data Resource. Accepted sequencing types include whole genome, exome, transcriptome, and justified epigenomic assays. All generated data, along with associated clinical and phenotypic information, will be integrated into the Kids First Data Resource Center for broad research community access and sharing. This initiative aims to advance understanding of pediatric disorders.
Opportunity ID: 351450
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-082 |
| Funding Opportunity Title: | Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 12, 2023 |
| Last Updated Date: | Dec 12, 2023 |
| Original Closing Date for Applications: | Mar 13, 2024 |
| Current Closing Date for Applications: | Mar 13, 2024 |
| Archive Date: | Apr 18, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Special district governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments State governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Independent school districts Public and State controlled institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer or structural birth defect cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of structural birth defects, to study the molecular basis of the associations between birth defects and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-082.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 351450 Full Announcement-PAR-24-082 -> PAR-24-082-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284140 | Feb 13, 2024 | Mar 13, 2024 | View |
Package 1
Mandatory forms
351450 RR_SF424_5_0-5.0.pdf
351450 PHS398_CoverPageSupplement_5_0-5.0.pdf
351450 RR_OtherProjectInfo_1_4-1.4.pdf
351450 RR_KeyPersonExpanded_4_0-4.0.pdf
351450 PHS398_ResearchPlan_5_0-5.0.pdf
351450 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
351450 PHS_AssignmentRequestForm_3_0-3.0.pdf
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