This grant, offered by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH) of the NIH, aims to address HIV-1 persistence in individuals on suppressive antiretroviral regimens. The initiative seeks applications for research in four key areas: identifying and characterizing HIV-1 cellular reservoirs, developing physiologically relevant assays for latent HIV-1, screening drug candidates targeting persistent virus, and developing/testing new eradication strategies. The core objective is to expand the knowledge base on HIV-1 latency and persistence, facilitating the design and evaluation of effective cure strategies. Successful applications must integrate basic research and translational activities, requiring collaboration with a private sector entity. This opportunity utilizes the U19 award mechanism.
Opportunity ID: 55504
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-10-009 |
| Funding Opportunity Title: | Martin Delaney Collaboratory: Towards an HIV-1 Cure (U19) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 28, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 04, 2010 |
| Current Closing Date for Applications: | Nov 04, 2010 |
| Archive Date: | Dec 05, 2010 |
| Estimated Total Program Funding: | $8,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH), National Institutes of Health (NIH), encourage grant applications from institutions/organizations to address the problem of HIV-1 persistence in HIV-1-infected persons treated with suppressive antiretroviral drug regimens. This FOA will support research in four areas: (1) basic research to identify and characterize the cellular reservoirs of HIV-1 in treated individuals, (2) development of assays that are physiologically relevant and that comprise a spectrum of cell types that may harbor latent HIV-1 or permit viral replication in the presence of effective antiretroviral drug regimens, (3) screening of drug candidates that target latent/persistent HIV-1, and (4) development and initial testing of new agents or strategies aimed at the eradication of HIV-1. The goal of this initiative is to expand the knowledge base on HIV-1 latency and persistence so that eradication strategies can be designed, developed and evaluated. The application must include basic research and translational activities as essential components, and collaborators must include a private sector entity. Mechanism of Support. This FOA will utilize the U19 award mechanism. Funds Available and Anticipated Number of Awards. For this funding opportunity, the total amount of funds available from NIAID and NIMH is $8.5M for fiscal year 2011. NIAID and NIMH expect to fund 1-2 awards. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-009.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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