This Small Business Innovative Research (SBIR) funding opportunity is designed to support small businesses in developing novel resources and methodologies for chemical toxicity testing. The grant aims to address the current limitation in toxicology, where studies primarily rely on a narrow range of laboratory rodent strains, potentially missing clinically relevant toxic responses due to genetic resistance. This initiative seeks to foster the creation of cost-effective, high-throughput screening systems, including diverse panels of cells or model organisms. The ultimate goal is to better reflect the inherent genetic variability within human populations, ensuring a more comprehensive and accurate assessment of individual susceptibility to chemical exposures. This program encompasses Phase I, Phase II, Direct to Phase II, and Fast Track applications.
Opportunity ID: 341632
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-22-006 |
| Funding Opportunity Title: | New Approaches for Incorporating Genetic Diversity into Toxicity Testing (R43/R44 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 30, 2022 |
| Last Updated Date: | Jun 30, 2022 |
| Original Closing Date for Applications: | Nov 08, 2022 |
| Current Closing Date for Applications: | Nov 08, 2022 |
| Archive Date: | Dec 14, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,838,436 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) supports Phase I (R43), Phase II (R44), Direct to Phase II (R44), and Fast Track (R44) Small Business Innovative Research (SBIR) grant applications from small businesses concerns (SBCs) to develop resources and approaches, including panels of cells or model organisms, that reflect the variability in human populations in chemical toxicity testing . Current toxicology testing is often limited to studies conducted in a small number of laboratory rodent strains, which can fail to identify clinically relevant toxicity if the conventional rodent strain is particularly resistant to the toxic effects of the test compound. Cost-effective screening systems with appropriate throughput are needed to better capture this variability in responses to chemical exposure in the population based on individual genetic susceptibility. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-22-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 341632 Full Announcement-RFA-ES-22-006 -> RFA-ES-22-006-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00275398 | Oct 08, 2022 | Nov 08, 2022 | View |
Package 1
Mandatory forms
341632 RR_SF424_5_0-5.0.pdf
341632 PHS398_CoverPageSupplement_5_0-5.0.pdf
341632 RR_OtherProjectInfo_1_4-1.4.pdf
341632 PerformanceSite_4_0-4.0.pdf
341632 RR_KeyPersonExpanded_4_0-4.0.pdf
341632 RR_Budget_3_0-3.0.pdf
341632 PHS398_ResearchPlan_4_0-4.0.pdf
341632 SBIR_STTR_Information_3_0-3.0.pdf
341632 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
341632 RR_SubawardBudget30_3_0-3.0.pdf
341632 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
