This grant is for basic and translational research examining the impact of the microbiome on Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD). Despite growing evidence for the microbiome’s role in overall health and various diseases, its specific contributions from the alimentary canal and other endogenous microbiota sources in AD/ADRD remain underexplored. This funding opportunity supports rigorous mechanistic studies delving into potential interactions between the microbiome and genetic and non-genetic molecular targets influencing AD/ADRD. Expected outcomes include addressing the clinical relevance of the microbiome in disease initiation, progression, or modification, ultimately aiming to develop improved therapeutic interventions for these debilitating conditions.
Opportunity ID: 341708
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-211 |
| Funding Opportunity Title: | Impact of the Microbiome-Gut-Brain Axis on Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 05, 2022 |
| Last Updated Date: | Jul 05, 2022 |
| Original Closing Date for Applications: | Oct 05, 2022 |
| Current Closing Date for Applications: | Oct 05, 2022 |
| Archive Date: | Nov 10, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments State governments County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications for basic and translational research on the impact of the microbiome on Alzheimers Disease and Alzheimers Disease Related Dementias (AD/ADRD). While there is growing evidence that the microbiome is an important factor that contributes to overall health and a variety of diseases and disorders, the role of the alimentary canaland other sources of endogenous microbiota in specific AD/ADRDs has not been adequately addressed. This FOA will support mechanistic research focused on a more rigorous in-depth examination of the potential interactions between the microbiome and genetic and non-genetic molecular targets that influence AD/ADRD. It is expected that these studies will address the clinical relevance of the microbiome on disease initiation, progression, or modification, and will lead ultimately to better therapeutic interventions. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-211.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 341708 Full Announcement-PAR-22-211 -> PAR-22-211-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00275529 | Sep 05, 2022 | Oct 05, 2022 | View |
Package 1
Mandatory forms
341708 RR_SF424_5_0-5.0.pdf
341708 PHS398_CoverPageSupplement_5_0-5.0.pdf
341708 RR_OtherProjectInfo_1_4-1.4.pdf
341708 PerformanceSite_4_0-4.0.pdf
341708 RR_KeyPersonExpanded_4_0-4.0.pdf
341708 PHS398_ResearchPlan_4_0-4.0.pdf
341708 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
341708 RR_Budget_3_0-3.0.pdf
341708 RR_SubawardBudget30_3_0-3.0.pdf
341708 PHS398_ModularBudget_1_2-1.2.pdf
341708 PHS_AssignmentRequestForm_3_0-3.0.pdf
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