This grant is for the purpose of advancing therapeutic strategies for Type 1 Diabetes (T1D). It specifically supports the innovative engineering of immune cells designed to precisely target the human pancreatic compartment. This novel approach aims to achieve two critical objectives: first, to acquire previously inaccessible insights into the intricate mechanisms of diabetes initiation and progression by reporting on disease dynamics. Second, to deliver highly specific, environment-responsive therapeutic interventions. Ultimately, the work funded by this grant seeks to restore vital islet health and effectively prevent the onset and progression of T1D, offering a new avenue for disease management.
Opportunity ID: 331642
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-21-005 |
| Funding Opportunity Title: | Immune Cell Engineering For Targeted Therapy And Disease Monitoring in Type 1 Diabetes (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 19, 2021 |
| Last Updated Date: | Feb 19, 2021 |
| Original Closing Date for Applications: | Jun 22, 2021 |
| Current Closing Date for Applications: | Jun 22, 2021 |
| Archive Date: | Jul 28, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $600,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts For profit organizations other than small businesses City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative will support the engineering of immune cells to target the human pancreatic compartment to report on previously inaccessible information about diabetes initiation and progression, and to deliver environment-specific therapeutic responses to restore islet health and prevent the progression to T1D. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-21-005.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00265589 | May 22, 2021 | Jun 22, 2021 | View |
Package 1
Mandatory forms
331642 RR_SF424_2_0-2.0.pdf
331642 PHS398_CoverPageSupplement_5_0-5.0.pdf
331642 RR_OtherProjectInfo_1_4-1.4.pdf
331642 PerformanceSite_2_0-2.0.pdf
331642 RR_KeyPersonExpanded_2_0-2.0.pdf
331642 PHS398_ResearchPlan_4_0-4.0.pdf
331642 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
331642 RR_Budget_1_4-1.4.pdf
331642 RR_SubawardBudget30_1_4-1.4.pdf
331642 PHS398_ModularBudget_1_2-1.2.pdf
331642 PHS_AssignmentRequestForm_3_0-3.0.pdf
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