This grant is for the purpose of establishing up to four dedicated Centers for the Investigation of Factor VIII immunogenicity (FVIII Centers). These specialized Centers will conduct in-depth research utilizing cross-disciplinary science and novel technologies to define the fundamental mechanisms involved in the development of anti-FVIII neutralizing antibodies, also known as FVIII inhibitors. The research will specifically focus on patients with congenital hemophilia A. By fostering collaborative, innovative approaches, this funding opportunity aims to significantly advance understanding of the FVIII immune response, ultimately contributing to strategies for preventing or overcoming inhibitor formation in affected individuals.
Opportunity ID: 292895
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-18-014 |
| Funding Opportunity Title: | Establishment of Research Centers to Investigate the FVIII Immune Response in Patients with Hemophilia A (U54) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.839 — Blood Diseases and Resources Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 30, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 06, 2017 |
| Current Closing Date for Applications: | Jul 06, 2017 |
| Archive Date: | Aug 11, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Special district governments Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities City or township governments State governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this Funding Opportunity Announcement (FOA) is to establish up to four Centers for the Investigation of Factor VIII immunogenicity (FVIII Centers). These Centers will utilize cross-disciplinary science and novel technologies to define the basic mechanisms involved in the development of anti-FVIII neutralizing antibodies, also known as FVIII inhibitors, in patients with congenital hemophilia A. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-18-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | FORMS-D | PKG00231733 | Jun 06, 2017 | Jul 06, 2017 | View |
Package 1
Mandatory forms
292895 RR_SF424_2_0-2.0.pdf
292895 PHS398_CoverPageSupplement_3_0-3.0.pdf
292895 RR_OtherProjectInfo_1_3-1.3.pdf
292895 PerformanceSite_2_0-2.0.pdf
292895 RR_KeyPersonExpanded_2_0-2.0.pdf
292895 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
292895 PHS_Additional_IndirectCosts-1.0.pdf
292895 PHS_AssignmentRequestForm-1.0.pdf
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