This department is offering a grant to address the significantly understudied role of systemic immune responses and inflammation in brain neurodegeneration contributing to Alzheimer’s Disease and Related Dementias (AD/ADRD). This grant is for establishing and supporting new multi-disciplinary collaborations between neuroscientists, particularly those with AD/ADRD expertise, and immunologists. The primary purpose is to expand the research base in this crucial area, aiming to integrate more immunology expertise into the AD/ADRD field. Individual projects are highly encouraged, especially those fostering partnerships focused on understanding how systemic immune signaling and inflammation impact AD/ADRD progression. The long-term goal is to build a solid research foundation that can sustain further advancements in this vital area of study.
Opportunity ID: 335159
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-023 |
| Funding Opportunity Title: | Multi-Disciplinary Collaborations to Understand Mechanisms of Systemic Immune Signaling and Inflammation in ADRD and its Progression (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2021 |
| Last Updated Date: | Aug 06, 2021 |
| Original Closing Date for Applications: | Oct 22, 2021 |
| Current Closing Date for Applications: | Oct 22, 2021 |
| Archive Date: | Nov 27, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) State governments Special district governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments City or township governments Private institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Recent findings have raised the hypothesis that systemic immune responses could play direct or indirect roles in brain neurodegeneration leading to AD/ADRD, and has been significantly less studied compared to innate immune mechanisms such as microglia in the brain. This initiative will capitalize on growing interest in the research community and will support partnerships and new collaborations between neuroscientists and immunologists to expand the research base in this area with the long-term goal of bringing more immunology expertise into the AD/ADRD field. This is a new initiative seeking research into the role of systemic immune responses and inflammation in AD/ADRD. Individual projects are sought and collaborations between neuroscientists with expertise in AD/ADRDs and immunologists will be highly encouraged. Through these awards, a more solid research base in this area will be established that can support further work in this area through investigator-initiated and other mechanisms. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-023.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268494 | Sep 22, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335159 RR_SF424_2_0-2.0.pdf
335159 PHS398_CoverPageSupplement_5_0-5.0.pdf
335159 RR_OtherProjectInfo_1_4-1.4.pdf
335159 PerformanceSite_2_0-2.0.pdf
335159 RR_KeyPersonExpanded_2_0-2.0.pdf
335159 PHS398_ResearchPlan_4_0-4.0.pdf
335159 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335159 RR_Budget_1_4-1.4.pdf
335159 RR_SubawardBudget30_1_4-1.4.pdf
335159 PHS398_ModularBudget_1_2-1.2.pdf
335159 PHS_AssignmentRequestForm_3_0-3.0.pdf
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