This grant, offered by the National Institutes of Health (NIH), aims to support the development of in vivo neurophysiological and behavioral measures in animal models. The primary purpose is to identify, optimize, and evaluate these measures for use as early screening assays in the therapeutic development pipeline for mental illnesses. By building on systems neurobiology and clinical neuroscience, the initiative seeks to establish robust surrogate markers of neural processes of clinical interest. The assays developed will enhance the scientific value of preclinical animal data, enabling the assessment of how therapeutic targets and treatment candidates impact neurobiological mechanisms relevant to mental illnesses, thereby accelerating the path to effective treatments.
Opportunity ID: 357285
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-035 |
| Funding Opportunity Title: | Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 21, 2024 |
| Last Updated Date: | Nov 21, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Private institutions of higher education City or township governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | SRF Reissue: The overall goal of this notice of funding opportunity (NOFO) is to identify, in animals, in vivo neurophysiological and behavioral measures for use as assays in the early screening phase of treatment development. The NOFO will support efforts to optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. The screening assays thus developed from this NOFO are expected to build upon systems neurobiology and clinical neuroscience to enhance the scientific value of preclinical animal data contributing to a therapeutic development pipeline by assessing the impact of therapeutic targets and treatment candidates on neurobiological mechanisms of clinical relevance to mental illnesses. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-035.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357285 Full Announcement-PAR-25-035 -> PAR-25-035-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288867 | Jan 05, 2025 | Sep 07, 2025 | View |
Package 1
Mandatory forms
357285 RR_SF424_5_0-5.0.pdf
357285 PHS398_CoverPageSupplement_5_0-5.0.pdf
357285 RR_OtherProjectInfo_1_4-1.4.pdf
357285 PerformanceSite_4_0-4.0.pdf
357285 RR_KeyPersonExpanded_4_0-4.0.pdf
357285 PHS398_ResearchPlan_5_0-5.0.pdf
357285 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357285 RR_Budget_3_0-3.0.pdf
357285 RR_SubawardBudget30_3_0-3.0.pdf
357285 PHS398_ModularBudget_1_2-1.2.pdf
357285 PHS_AssignmentRequestForm_4_0-4.0.pdf
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