This NIH Neuroscience grant invites proposals to investigate biological and clinical measures of progressive neurodegeneration and cognitive decline following Traumatic Brain Injury (TBI). The research aims to understand TBI-related dementia and Traumatic Encephalopathy Syndrome (TES), the clinical form of Chronic Traumatic Encephalopathy (CTE). Studies must utilize existing, well-characterized TBI patient populations at risk for cognitive impairment, suitable for longitudinal follow-up. The overarching goal is to advance knowledge of TBI’s chronic effects, distinguishing stable cognitive impairment from progressive neurodegeneration leading to TES and dementia. A key requirement is extensive sharing of clinical, neuroimaging, physiological, and biospecimen data, creating a vital resource for the broader research community.
Opportunity ID: 335238
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-024 |
| Funding Opportunity Title: | Clinical and Biological Measures of TBI-related Dementia Including Chronic Traumatic Encephalopathy (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 10, 2021 |
| Last Updated Date: | Aug 10, 2021 |
| Original Closing Date for Applications: | Nov 10, 2021 |
| Current Closing Date for Applications: | Nov 10, 2021 |
| Archive Date: | Dec 16, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments City or township governments State governments Native American tribal governments (Federally recognized) Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA invites investigation of biological and clinical measures of TBI-related progressive neurodegeneration and neurocognitive decline associated with increased risk for dementia and /or traumatic encephalopathy syndrome (TES) (clinicopathologic diagnostic counterpart to the neuropathological diagnosis of Chronic Traumatic Encephalopathy (CTE)). Investigations should be based on existing, well-characterized populations of patients with a history of TBI that are enriched for increased risk of cognitive impairment or dementia and can continue to be followed longitudinally; additional subjects may be recruited as appropriate. The overall goal is to advance knowledge of the underlying pathophysiology and clinical characterization of the chronic effects of TBI that distinguish static-chronic TBI cognitive impairment from those that lead to progressive neurodegeneration associated with TES and dementia. A critical feature of this FOA includes the broad sharing of clinical, neuroimaging, physiological, and biospecimen data and to create a data and associated biofluid resource for the broader community to further advance research in this area. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-024.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269845 | Oct 28, 2021 | Nov 10, 2021 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268523 | Oct 10, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335238 RR_SF424_5_0-5.0.pdf
335238 PHS398_CoverPageSupplement_5_0-5.0.pdf
335238 RR_OtherProjectInfo_1_4-1.4.pdf
335238 PerformanceSite_4_0-4.0.pdf
335238 RR_KeyPersonExpanded_4_0-4.0.pdf
335238 PHS398_ResearchPlan_4_0-4.0.pdf
335238 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
335238 RR_Budget_3_0-3.0.pdf
335238 RR_SubawardBudget30_3_0-3.0.pdf
335238 PHS398_ModularBudget_1_2-1.2.pdf
335238 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
335238 RR_SF424_2_0-2.0.pdf
335238 PHS398_CoverPageSupplement_5_0-5.0.pdf
335238 RR_OtherProjectInfo_1_4-1.4.pdf
335238 PerformanceSite_2_0-2.0.pdf
335238 RR_KeyPersonExpanded_2_0-2.0.pdf
335238 PHS398_ResearchPlan_4_0-4.0.pdf
335238 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335238 RR_Budget_1_4-1.4.pdf
335238 RR_SubawardBudget30_1_4-1.4.pdf
335238 PHS398_ModularBudget_1_2-1.2.pdf
335238 PHS_AssignmentRequestForm_3_0-3.0.pdf
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