This NHLBI grant is for establishing a Data Coordinating Center (DCC) to support the new Pulmonary Vascular Disease Phenomics Program (PVDOMICS). PVDOMICS will conduct comprehensive, deep phenotyping of patients with pulmonary hypertension (PH) across all WHO-classified groups. The goal is to generate novel subclassifications of patients based on molecular, radiographic, and clinical characteristics, linking them to specific disease mechanisms. This research aims to identify new endophenotypes of lung vascular disease and critical biomarkers useful for early diagnosis or evaluating therapeutic interventions. The DCC will manage data from parallel Clinical Centers, all adhering to a common phenotyping protocol to advance understanding and treatment of pulmonary vascular-right ventricular disease.
Opportunity ID: 248301
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-14-030 |
| Funding Opportunity Title: | Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Data Coordinating Center (DCC) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 25, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 29, 2014 |
| Current Closing Date for Applications: | Jan 29, 2014 |
| Archive Date: | Mar 01, 2014 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments City or township governments For profit organizations other than small businesses Independent school districts Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to invite applications to participate in a new NHLBI Pulmonary Vascular Disease Phenomics Program (hereafter referred to as “PVDOMICS”). Teams of investigators will perform comprehensive, deep phenotyping across the current World Health Organization (WHO)-classified pulmonary hypertension (PH) clinical Groups 1 through 5 (http://www.nhlbi.nih.gov/health/health-topics/topics/pah/types.html), which will lead to novel subclassifications of patients with pulmonary vascular-right ventricular disease, based on molecular and radiographic as well as clinical characteristics, which can be associated with specific molecular mechanisms of pathogenesis. This research is intended to lead to identification of both endophenotypes of lung vascular disease and biomarkers of disease that may be useful for early diagnosis or for assessment of interventions to prevent or treat this condition. This FOA solicits applications for the Data Coordinating Center (DCC) and runs in parallel with a separate FOA that solicits applications for the Clinical Centers (CCs) (RFA HL-14-027). The common phenotyping protocol will be aimed at: |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-14-030.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.838 | FORMS-C | Forms-C | PKG00190150 | Dec 29, 2013 | Jan 29, 2014 | View |
Package 1
Mandatory forms
248301 RR_SF424_2_0-2.0.pdf
248301 PHS398_ResearchPlan_2_0-2.0.pdf
248301 PHS398_CoverPageSupplement_2_0-2.0.pdf
248301 RR_KeyPersonExpanded_2_0-2.0.pdf
248301 RR_OtherProjectInfo_1_3-1.3.pdf
248301 PerformanceSite_2_0-2.0.pdf
Optional forms
248301 RR_SubawardBudget30_1_3-1.3.pdf
248301 PlannedReport-1.0.pdf
248301 PHS398_CumulativeInclusionReport-1.0.pdf
248301 PHS398_ModularBudget_1_2-1.2.pdf
248301 RR_Budget_1_3-1.3.pdf
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