This NIH Exploratory/Developmental Grant, part of the HEAL Initiative, supports high-risk, high-reward basic research projects. It invites applications to investigate the impact of opioids, potentially combined with other substances, on placenta function and neurodevelopment during pregnancy and the first year of life. Studies must utilize experimental designs prospectively assigning human participants to conditions, assessing biomedical and behavioral outcomes to understand fundamental phenomena related to opioid exposure. This grant specifically targets Basic Experimental Studies with Humans (BESH) that align with NIH’s definitions of both basic research and clinical trials, without aiming for clinical outcomes or products. Applications proposing animal or observational human studies should refer to the companion RFA-HD-23-031.
Opportunity ID: 343291
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HD-23-033 |
| Funding Opportunity Title: | HEAL Initiative: Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R21 Basic Experimental Studies with Humans Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 29, 2022 |
| Last Updated Date: | Aug 29, 2022 |
| Original Closing Date for Applications: | Dec 07, 2022 |
| Current Closing Date for Applications: | Dec 07, 2022 |
| Archive Date: | Jan 12, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education State governments County governments Special district governments For profit organizations other than small businesses Independent school districts Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Funding Opportunity Announcement (FOA) invites Exploratory/Developmental Grant applications to study the impact of opioids, alone or in combination with other substances of misuse, on placenta function and neurodevelopment during pregnancy and in the first year of life using experimental designs that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical and/or behavioral outcomes in humans to understand fundamental aspects of phenomena related to opioid exposure during pregnancy. NIH considers such studies as Basic Experimental Studies with Humans (BESH), or prospective basic science studies involving human participants that meet the NIH definition of basic research and fall within the NIH definition of clinical trials (see, e.g., NOT-OD-19-024). Applications should not propose a goal of clinical outcomes or products. Applications that propose studies including model animal research or observational studies involving humans should submit under the companion FOA, RFA-HD-23-031,”Opioid Exposure and Effects on Placenta Function, Brain Development, and Neurodevelopmental Outcomes (R21 Clinical Trials Not Allowed). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-HD-23-033.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00276588 | Nov 07, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278174 | Nov 08, 2022 | Dec 07, 2022 | View |
Package 1
Mandatory forms
343291 RR_SF424_5_0-5.0.pdf
343291 PHS398_CoverPageSupplement_5_0-5.0.pdf
343291 RR_OtherProjectInfo_1_4-1.4.pdf
343291 PerformanceSite_4_0-4.0.pdf
343291 RR_KeyPersonExpanded_4_0-4.0.pdf
343291 PHS398_ResearchPlan_4_0-4.0.pdf
343291 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343291 RR_Budget_3_0-3.0.pdf
343291 RR_SubawardBudget30_3_0-3.0.pdf
343291 PHS398_ModularBudget_1_2-1.2.pdf
343291 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343291 RR_SF424_5_0-5.0.pdf
343291 PHS398_CoverPageSupplement_5_0-5.0.pdf
343291 RR_OtherProjectInfo_1_4-1.4.pdf
343291 PerformanceSite_4_0-4.0.pdf
343291 RR_KeyPersonExpanded_4_0-4.0.pdf
343291 PHS398_ResearchPlan_5_0-5.0.pdf
343291 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343291 RR_Budget_3_0-3.0.pdf
343291 RR_SubawardBudget30_3_0-3.0.pdf
343291 PHS398_ModularBudget_1_2-1.2.pdf
343291 PHS_AssignmentRequestForm_3_0-3.0.pdf
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