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Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)

Opportunity ID: 361213

General Information

Funding Opportunity Number RFA-DK-27-112
Funding Opportunity Title Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Agency National Institutes of Health
Document Type synopsis
Version 1
Opportunity Category Discretionary
Opportunity Category Explanation Not specified
Funding Instrument Type Cooperative Agreement
Category of Funding Activity Health
Category Explanation Not specified
Expected Number of Awards 1
Cost Sharing or Matching Requirement No
Posted Date Aug 31, 2026 12:00:00 AM EDT
Last Updated Date Aug 31, 2026 10:20:25 AM EDT
Original Closing Date Nov 09, 2026 12:00:00 AM EST
Original Closing Date Notes Not specified
Current Closing Date Nov 09, 2026 12:00:00 AM EST
Current Closing Date Notes Not specified
Estimated Synopsis Date Not specified
Estimated Application Due Date Not specified
Estimated Award Date Not specified
Estimated Project Start Date Not specified
Archive Date Jan 08, 2027 12:00:00 AM EST
Estimated Total Program Funding 6,300,000
Award Ceiling none
Award Floor none

Assistance Listings

  • 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research

Eligibility

Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)

This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Description

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, applications will be peer-reviewed, and only meritorious applications will be considered for funding. Through this NOFO, the National institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites an application to continue to follow the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort through a collaborative cooperative agreement that addresses specific knowledge gaps in the development and progression of type 1 diabetes complications. Applications should include hypothesis-based research, support for cohort infrastructure and/or maintenance, continued follow-up, and supporting collaborative research to utilize the EDIC cohort as well as its data set and biologic/genetic samples.

Additional Information

Contact National Institutes of Health
Contact Information Division of Diabetes, Endocrinology and Metabolic Diseases
NIDDK_DEM@nih.gov
Email NIDDK_DEM@nih.gov
Email Description NIDDK_DEM@nih.gov
Phone 301-402-2541

Additional information

Version History

Version history

Opp hist id / Opportunity id 361213
Opp hist id / Revision 1
Opportunity id 361213
Revision 1
Opportunity number RFA-DK-27-112
Opportunity title Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Owning agency code HHS-NIH11
Opportunity category / Category D
Opportunity category / Description Discretionary
Forecast / Opp hist id / Opportunity id 361213
Forecast / Opp hist id / Revision 1
Forecast / Opportunity id 361213
Forecast / Revision 1
Forecast / Version 1
Forecast / Posting date Jan 29, 2026 12:00:00 AM EST
Forecast / Forecast desc The primary purpose of this FOA is to support the EDIC Research Center in continuing long-term follow-up of the EDIC cohort to study the development and progression of complications in type 1 diabetes (T1D). The research will address severe microvascular disease, cardiovascular and liver disease, sleep disorders, mortality, and other comorbidities. The goals are to investigate the trajectory of age-related morbidities such as cognition, physical function, and frailty, and to identify their associations with risk factors that affect quality of life, self-management, and caregiver burden. Particular emphasis will be placed on evaluating the impact of emerging therapies, including SGLT2 inhibitors and GLP-1 receptor agonists, on renal and cardiovascular outcomes.
The initiative also encourages the application of advanced statistical methods, including machine learning and artificial intelligence, to identify phenotypes that are either susceptible or resilient to diabetes-related complications. Modern technologies, such as continuous glucose monitoring, coronary calcification imaging, and vascular tonometry, will be used and compared with data from existing cohorts. In addition, the program will support assessments of obesity-related outcomes and comorbidities—including metabolic-associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA)—within the increasingly overweight/obese T1D population. Multi-omic approaches to identify biochemical signatures associated with complications are also expected. Finally, the leveraging of external databases to examine the cost-effectiveness and quality-of-life impact of intensive therapy across the lifespan will be encouraged.
This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Forecast / Cost sharing No
Forecast / Number of awards 1
Forecast / Estimated funding 6300000
Forecast / Agency contact name Division of Diabetes, Endocrinology and Metabolic Diseases
Forecast / Agency contact phone NIDDK_DEM@nih.gov
Forecast / Agency contact email NIDDK_DEM@nih.gov
Forecast / Agency contact email desc NIDDK_DEM@nih.gov
Forecast / Agency code HHS-NIH11
Forecast / Applicant eligibility desc This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Forecast / Est synopsis posting date Apr 01, 2026 12:00:00 AM EDT
Forecast / Est application response date Jul 01, 2026 12:00:00 AM EDT
Forecast / Est award date Oct 01, 2026 12:00:00 AM EDT
Forecast / Est project start date Jul 01, 2027 12:00:00 AM EDT
Forecast / Fiscal year 2027
Forecast / Create time stamp Jan 29, 2026 12:18:30 PM EST
Forecast / Action type U
Forecast / Action date Aug 31, 2026 10:20:25 AM EDT
Forecast / Created date Jan 29, 2026 12:18:30 PM EST
Forecast / Last updated date Jan 29, 2026 12:18:30 PM EST
Forecast / Agency details / Code NIH
Forecast / Agency details / Seed HHS-NIH11
Forecast / Agency details / Agency name National Institutes of Health
Forecast / Agency details / Agency code HHS-NIH11
Forecast / Agency details / Top agency code HHS
Forecast / Estimated funding formatted 6,300,000
Forecast / Applicant types 1 / Id 06
Forecast / Applicant types 1 / Description Public and State controlled institutions of higher education
Forecast / Applicant types 2 / Id 20
Forecast / Applicant types 2 / Description Private institutions of higher education
Forecast / Funding instruments 1 / Id CA
Forecast / Funding instruments 1 / Description Cooperative Agreement
Forecast / Funding activity categories 1 / Id HL
Forecast / Funding activity categories 1 / Description Health
Forecast / Posting date str 2026-01-29-00-00-00
Forecast / Est synopsis posting date str 2026-04-01-00-00-00
Forecast / Est application response date str 2026-07-01-00-00-00
Forecast / Est award date str 2026-10-01-00-00-00
Forecast / Est project start date str 2027-07-01-00-00-00
Forecast / Create time stamp str 2026-01-29-12-18-30
Cfdas 1 / Id 431845
Cfdas 1 / Opportunity id 361213
Cfdas 1 / Revision 0
Cfdas 1 / Cfda number 93.847
Cfdas 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Synopsis modified fields Not specified
Forecast modified fields Not specified

Forecast changes

revision

version

archiveDate

modComments

createTimeStamp

Id 361213
Revision 2
Opportunity number RFA-DK-27-112
Opportunity title Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Owning agency code HHS-NIH11
Opportunity category / Category D
Opportunity category / Description Discretionary
Synopsis / Opportunity id 361213
Synopsis / Version 1
Synopsis / Agency code HHS-NIH11
Synopsis / Agency name National Institutes of Health
Synopsis / Agency phone 301-402-2541
Synopsis / Agency address desc NIDDK_DEM@nih.gov
Synopsis / Agency details / Code NIH
Synopsis / Agency details / Seed HHS-NIH11
Synopsis / Agency details / Agency name National Institutes of Health
Synopsis / Agency details / Agency code HHS-NIH11
Synopsis / Agency details / Top agency code HHS
Synopsis / Top agency details / Code HHS
Synopsis / Top agency details / Seed HHS
Synopsis / Top agency details / Agency name Department of Health and Human Services
Synopsis / Top agency details / Agency code HHS
Synopsis / Top agency details / Top agency code HHS
Synopsis / Agency contact phone 301-402-2541
Synopsis / Agency contact name National Institutes of Health
Synopsis / Agency contact desc Division of Diabetes, Endocrinology and Metabolic Diseases
NIDDK_DEM@nih.gov
Synopsis / Agency contact email NIDDK_DEM@nih.gov
Synopsis / Agency contact email desc NIDDK_DEM@nih.gov
Synopsis / Synopsis desc This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, applications will be peer-reviewed, and only meritorious applications will be considered for funding. Through this NOFO, the National institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites an application to continue to follow the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort through a collaborative cooperative agreement that addresses specific knowledge gaps in the development and progression of type 1 diabetes complications. Applications should include hypothesis-based research, support for cohort infrastructure and/or maintenance, continued follow-up, and supporting collaborative research to utilize the EDIC cohort as well as its data set and biologic/genetic samples.
Synopsis / Response date Nov 09, 2026 12:00:00 AM EST
Synopsis / Posting date Aug 31, 2026 12:00:00 AM EDT
Synopsis / Archive date Jan 08, 2027 12:00:00 AM EST
Synopsis / Cost sharing No
Synopsis / Number of awards 1
Synopsis / Estimated funding 6300000
Synopsis / Estimated funding formatted 6,300,000
Synopsis / Award ceiling none
Synopsis / Award floor none
Synopsis / Applicant eligibility desc This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Synopsis / Create time stamp Aug 31, 2026 10:20:35 AM EDT
Synopsis / Created date Aug 31, 2026 10:20:25 AM EDT
Synopsis / Last updated date Aug 31, 2026 10:20:25 AM EDT
Synopsis / Applicant types 1 / Id 25
Synopsis / Applicant types 1 / Description Others (see text field entitled "Additional Information on Eligibility" for clarification)
Synopsis / Funding instruments 1 / Id CA
Synopsis / Funding instruments 1 / Description Cooperative Agreement
Synopsis / Funding activity categories 1 / Id HL
Synopsis / Funding activity categories 1 / Description Health
Synopsis / Response date str 2026-11-09-00-00-00
Synopsis / Posting date str 2026-08-31-00-00-00
Synopsis / Archive date str 2027-01-08-00-00-00
Synopsis / Create time stamp str 2026-08-31-10-20-35
Agency details / Code NIH
Agency details / Seed HHS-NIH11
Agency details / Agency name National Institutes of Health
Agency details / Agency code HHS-NIH11
Agency details / Top agency code HHS
Top agency details / Code HHS
Top agency details / Seed HHS
Top agency details / Agency name Department of Health and Human Services
Top agency details / Agency code HHS
Top agency details / Top agency code HHS
Forecast / Opportunity id 361213
Forecast / Version 2
Forecast / Posting date Jan 29, 2026 12:00:00 AM EST
Forecast / Archive date Aug 30, 2026 12:00:00 AM EDT
Forecast / Forecast desc The primary purpose of this FOA is to support the EDIC Research Center in continuing long-term follow-up of the EDIC cohort to study the development and progression of complications in type 1 diabetes (T1D). The research will address severe microvascular disease, cardiovascular and liver disease, sleep disorders, mortality, and other comorbidities. The goals are to investigate the trajectory of age-related morbidities such as cognition, physical function, and frailty, and to identify their associations with risk factors that affect quality of life, self-management, and caregiver burden. Particular emphasis will be placed on evaluating the impact of emerging therapies, including SGLT2 inhibitors and GLP-1 receptor agonists, on renal and cardiovascular outcomes.
The initiative also encourages the application of advanced statistical methods, including machine learning and artificial intelligence, to identify phenotypes that are either susceptible or resilient to diabetes-related complications. Modern technologies, such as continuous glucose monitoring, coronary calcification imaging, and vascular tonometry, will be used and compared with data from existing cohorts. In addition, the program will support assessments of obesity-related outcomes and comorbidities—including metabolic-associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA)—within the increasingly overweight/obese T1D population. Multi-omic approaches to identify biochemical signatures associated with complications are also expected. Finally, the leveraging of external databases to examine the cost-effectiveness and quality-of-life impact of intensive therapy across the lifespan will be encouraged.
This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Forecast / Cost sharing No
Forecast / Number of awards 1
Forecast / Estimated funding 6300000
Forecast / Agency contact name Division of Diabetes, Endocrinology and Metabolic Diseases
Forecast / Agency contact phone NIDDK_DEM@nih.gov
Forecast / Agency contact email NIDDK_DEM@nih.gov
Forecast / Agency contact email desc NIDDK_DEM@nih.gov
Forecast / Agency code HHS-NIH11
Forecast / Applicant eligibility desc This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Forecast / Est synopsis posting date Apr 01, 2026 12:00:00 AM EDT
Forecast / Est application response date Jul 01, 2026 12:00:00 AM EDT
Forecast / Est award date Oct 01, 2026 12:00:00 AM EDT
Forecast / Est project start date Jul 01, 2027 12:00:00 AM EDT
Forecast / Fiscal year 2027
Forecast / Mod comments Updated Archive Date
Forecast / Create time stamp Aug 31, 2026 10:20:35 AM EDT
Forecast / Created date Jan 29, 2026 12:18:30 PM EST
Forecast / Last updated date Aug 31, 2026 10:20:35 AM EDT
Forecast / Agency details / Code NIH
Forecast / Agency details / Seed HHS-NIH11
Forecast / Agency details / Agency name National Institutes of Health
Forecast / Agency details / Agency code HHS-NIH11
Forecast / Agency details / Top agency code HHS
Forecast / Estimated funding formatted 6,300,000
Forecast / Applicant types 1 / Id 20
Forecast / Applicant types 1 / Description Private institutions of higher education
Forecast / Applicant types 2 / Id 06
Forecast / Applicant types 2 / Description Public and State controlled institutions of higher education
Forecast / Funding instruments 1 / Id CA
Forecast / Funding instruments 1 / Description Cooperative Agreement
Forecast / Funding activity categories 1 / Id HL
Forecast / Funding activity categories 1 / Description Health
Forecast / Posting date str 2026-01-29-00-00-00
Forecast / Archive date str 2026-08-30-00-00-00
Forecast / Est synopsis posting date str 2026-04-01-00-00-00
Forecast / Est application response date str 2026-07-01-00-00-00
Forecast / Est award date str 2026-10-01-00-00-00
Forecast / Est project start date str 2027-07-01-00-00-00
Forecast / Create time stamp str 2026-08-31-10-20-35
Synopsis attachment folders 1 / Id 81208
Synopsis attachment folders 1 / Opportunity id 361213
Synopsis attachment folders 1 / Folder type Full Announcement
Synopsis attachment folders 1 / Folder name Full Announcement
Synopsis attachment folders 1 / Zip lob size 30877
Synopsis attachment folders 1 / Created date Aug 31, 2026 10:20:34 AM EDT
Synopsis attachment folders 1 / Last updated date Aug 31, 2026 10:20:35 AM EDT
Synopsis attachment folders 1 / Synopsis attachments 1 / Id 354874
Synopsis attachment folders 1 / Synopsis attachments 1 / Opportunity id 361213
Synopsis attachment folders 1 / Synopsis attachments 1 / Mime type text/html;charset=UTF-8
Synopsis attachment folders 1 / Synopsis attachments 1 / File name RFA-DK-27-112-Full-Announcement.html
Synopsis attachment folders 1 / Synopsis attachments 1 / File description RFA-DK-27-112-Full-Announcement.html
Synopsis attachment folders 1 / Synopsis attachments 1 / File lob size 136225
Synopsis attachment folders 1 / Synopsis attachments 1 / Created date Aug 31, 2026 10:20:35 AM EDT
Synopsis attachment folders 1 / Synopsis attachments 1 / Synopsis att folder id 81208
Synopsis document urls Not specified
Syn att change comments Not specified
Cfdas 1 / Id 431845
Cfdas 1 / Opportunity id 361213
Cfdas 1 / Cfda number 93.847
Cfdas 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Opportunity pkgs 1 / Id 294084
Opportunity pkgs 1 / Topportunity id 361213
Opportunity pkgs 1 / Family id 14
Opportunity pkgs 1 / Dialect XFDL2.2
Opportunity pkgs 1 / Opportunity number RFA-DK-27-112
Opportunity pkgs 1 / Opportunity title Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Opportunity pkgs 1 / Cfda number 93.847
Opportunity pkgs 1 / Opening date 2026-10-09
Opportunity pkgs 1 / Closing date 2026-11-09
Opportunity pkgs 1 / Owning agency code HHS-NIH11
Opportunity pkgs 1 / Agency details / Code NIH
Opportunity pkgs 1 / Agency details / Seed HHS-NIH11
Opportunity pkgs 1 / Agency details / Agency name National Institutes of Health
Opportunity pkgs 1 / Agency details / Agency code HHS-NIH11
Opportunity pkgs 1 / Agency details / Top agency code HHS
Opportunity pkgs 1 / Top agency details / Code HHS
Opportunity pkgs 1 / Top agency details / Seed HHS
Opportunity pkgs 1 / Top agency details / Agency name Department of Health and Human Services
Opportunity pkgs 1 / Top agency details / Agency code HHS
Opportunity pkgs 1 / Top agency details / Top agency code HHS
Opportunity pkgs 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Opportunity pkgs 1 / Contact info eRA Service Desk
https://www.era.nih.gov/need-help
Opportunity pkgs 1 / Grace period 60
Opportunity pkgs 1 / Competition id FORMS-I
Opportunity pkgs 1 / Competition title Use for due date on or after January 25, 2025.
Opportunity pkgs 1 / Electronic required Y
Opportunity pkgs 1 / Expected application count 100
Opportunity pkgs 1 / Open to applicant type 1
Opportunity pkgs 1 / Is multi project N
Opportunity pkgs 1 / Extension pdf
Opportunity pkgs 1 / Mimetype application/pdf
Opportunity pkgs 1 / Last update Aug 31, 2026 10:20:52 AM EDT
Opportunity pkgs 1 / Workspace compatible flag Y
Opportunity pkgs 1 / Package id PKG00294084
Opportunity pkgs 1 / Opening date str 2026-10-09-00-00-00
Opportunity pkgs 1 / Closing date str 2026-11-09-00-00-00
Closed opportunity pkgs Not specified
Original due date Nov 09, 2026 12:00:00 AM EST
Synopsis modified fields Not specified
Forecast modified fields revision; version; archiveDate; modComments; createTimeStamp
Error messages Not specified
Syn post date in past Yes
Doc type synopsis
Forecast hist count 0
Synopsis hist count 0
Assist compatible No
Assist url Not specified
Related opps Not specified
Ost POSTED

Related Documents

There are no related documents on this grant.

Packages

Agency Contact Information: Division of Diabetes, Endocrinology and Metabolic Diseases
NIDDK_DEM@nih.gov
Assistance Listing Number Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions
93.847 FORMS-I Use for due date on or after January 25, 2025. PKG00294084 2026-10-09 2026-11-09 View

Package 1

Instructions

PKG00294120-instructions.pdf

Mandatory forms

RR_SF424_5_0-V5.0.pdf
PHS398_CoverPageSupplement_5_0-V5.0.pdf
RR_OtherProjectInfo_1_4-V1.4.pdf
PerformanceSite_4_0-V4.0.pdf
RR_KeyPersonExpanded_4_0-V4.0.pdf
PHS398_ResearchPlan_5_0-V5.0.pdf
PHSHumanSubjectsAndClinicalTrialsInfo_3_0-V3.0.pdf

Optional forms

RR_Budget_3_0-V3.0.pdf
RR_SubawardBudget30_3_0-V3.0.pdf
PHS398_ModularBudget_1_2-V1.2.pdf
PHS_AssignmentRequestForm_4_0-V4.0.pdf

osnqt2026-09-15T23:23:16-05:00

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