Opportunity ID: 360404
General Information
| Funding Opportunity Number | PAR-27-065 |
| Funding Opportunity Title | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Agency | National Institutes of Health |
| Document Type | synopsis |
| Version | 1 |
| Opportunity Category | Discretionary |
| Opportunity Category Explanation | Not specified |
| Funding Instrument Type | Cooperative Agreement |
| Category of Funding Activity | Health |
| Category Explanation | Not specified |
| Expected Number of Awards | Not specified |
| Cost Sharing or Matching Requirement | No |
| Posted Date | Aug 31, 2026 12:00:00 AM EDT |
| Last Updated Date | Aug 31, 2026 10:35:01 AM EDT |
| Original Closing Date | Mar 09, 2029 12:00:00 AM EST |
| Original Closing Date Notes | Not specified |
| Current Closing Date | Mar 09, 2029 12:00:00 AM EST |
| Current Closing Date Notes | Not specified |
| Estimated Synopsis Date | Not specified |
| Estimated Application Due Date | Not specified |
| Estimated Award Date | Not specified |
| Estimated Project Start Date | Not specified |
| Archive Date | May 08, 2029 12:00:00 AM EDT |
| Estimated Total Program Funding | Not specified |
| Award Ceiling | none |
| Award Floor | none |
Assistance Listings
- 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Eligibility
| Eligible Applicants | Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; State governments; Special district governments; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); City or township governments; Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; Private institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Description
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.
Additional Information
| Contact | National Institutes of Health |
| Contact Information | Exploratory_Efficacy_Trials@ninds.nih.gov Exploratory_Efficacy_Trials@ninds.nih.gov |
| Exploratory_Efficacy_Trials@ninds.nih.gov | |
| Email Description | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Phone | 301-402-2541 |
Additional information
Version History
Version history
| Opp hist id / Opportunity id | 360404 |
| Opp hist id / Revision | 0 |
| Opportunity id | 360404 |
| Revision | 0 |
| Opportunity number | PAR-26-069 |
| Opportunity title | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Forecast / Opp hist id / Opportunity id | 360404 |
| Forecast / Opp hist id / Revision | 0 |
| Forecast / Opportunity id | 360404 |
| Forecast / Revision | 0 |
| Forecast / Version | 1 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on exploratory and efficacy clinical trials that address questions within the mission and research interests of the NINDS and may evaluate drugs, biologics, and devices, as well as surgical, behavioral and rehabilitation therapies. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into the mission and research interests of the NINDS, found at the NINDS website (https://www.ninds.nih.gov/), are encouraged to begin to consider applying for this new NOFO. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Jeremy Brown, MD |
| Forecast / Agency contact phone | Please contact via e-mail. |
| Forecast / Agency contact email | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency contact email desc | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Nov 12, 2025 12:00:00 AM EST |
| Forecast / Est application response date | Feb 10, 2026 12:00:00 AM EST |
| Forecast / Est award date | Nov 01, 2026 12:00:00 AM EDT |
| Forecast / Est project start date | Dec 01, 2026 12:00:00 AM EST |
| Forecast / Fiscal year | 2026 |
| Forecast / Create time stamp | Aug 28, 2025 03:37:53 PM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 09:33:48 AM EDT |
| Forecast / Created date | Aug 28, 2025 03:37:53 PM EDT |
| Forecast / Last updated date | Aug 28, 2025 03:37:53 PM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 04 |
| Forecast / Applicant types 1 / Description | Special district governments |
| Forecast / Applicant types 2 / Id | 02 |
| Forecast / Applicant types 2 / Description | City or township governments |
| Forecast / Applicant types 3 / Id | 00 |
| Forecast / Applicant types 3 / Description | State governments |
| Forecast / Applicant types 4 / Id | 22 |
| Forecast / Applicant types 4 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 5 / Id | 07 |
| Forecast / Applicant types 5 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 6 / Id | 11 |
| Forecast / Applicant types 6 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 7 / Id | 12 |
| Forecast / Applicant types 7 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 8 / Id | 13 |
| Forecast / Applicant types 8 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 9 / Id | 20 |
| Forecast / Applicant types 9 / Description | Private institutions of higher education |
| Forecast / Applicant types 10 / Id | 06 |
| Forecast / Applicant types 10 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 11 / Id | 01 |
| Forecast / Applicant types 11 / Description | County governments |
| Forecast / Applicant types 12 / Id | 08 |
| Forecast / Applicant types 12 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 13 / Id | 05 |
| Forecast / Applicant types 13 / Description | Independent school districts |
| Forecast / Applicant types 14 / Id | 23 |
| Forecast / Applicant types 14 / Description | Small businesses |
| Forecast / Applicant types 15 / Id | 25 |
| Forecast / Applicant types 15 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-12-00-00-00 |
| Forecast / Est application response date str | 2026-02-10-00-00-00 |
| Forecast / Est award date str | 2026-11-01-00-00-00 |
| Forecast / Est project start date str | 2026-12-01-00-00-00 |
| Forecast / Create time stamp str | 2025-08-28-15-37-53 |
| Cfdas 1 / Id | 430761 |
| Cfdas 1 / Opportunity id | 360404 |
| Cfdas 1 / Revision | 1 |
| Cfdas 1 / Cfda number | 93.853 |
| Cfdas 1 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Synopsis modified fields | Not specified |
| Forecast modified fields | Not specified |
| Opp hist id / Opportunity id | 360404 |
| Opp hist id / Revision | 2 |
| Opportunity id | 360404 |
| Revision | 2 |
| Opportunity number | PAR-27-065 |
| Opportunity title | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Modified comments | Updated details to match current NOFO. |
| Forecast / Opp hist id / Opportunity id | 360404 |
| Forecast / Opp hist id / Revision | 2 |
| Forecast / Opportunity id | 360404 |
| Forecast / Revision | 2 |
| Forecast / Version | 2 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on exploratory and efficacy clinical trials that address questions within the mission and research interests of the NINDS and may evaluate drugs, biologics, and devices, as well as surgical, behavioral and rehabilitation therapies. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into the mission and research interests of the NINDS, found at the NINDS website (https://www.ninds.nih.gov/), are encouraged to begin to consider applying for this new NOFO. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Jeremy Brown, MD |
| Forecast / Agency contact phone | Please contact via e-mail. |
| Forecast / Agency contact email | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency contact email desc | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Nov 12, 2025 12:00:00 AM EST |
| Forecast / Est application response date | Feb 10, 2026 12:00:00 AM EST |
| Forecast / Est award date | Nov 01, 2026 12:00:00 AM EDT |
| Forecast / Est project start date | Dec 01, 2026 12:00:00 AM EST |
| Forecast / Fiscal year | 2026 |
| Forecast / Mod comments | Updated details to match current NOFO. |
| Forecast / Create time stamp | Aug 31, 2026 09:33:48 AM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 10:35:02 AM EDT |
| Forecast / Created date | Aug 28, 2025 03:37:53 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 09:33:48 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 04 |
| Forecast / Applicant types 1 / Description | Special district governments |
| Forecast / Applicant types 2 / Id | 02 |
| Forecast / Applicant types 2 / Description | City or township governments |
| Forecast / Applicant types 3 / Id | 00 |
| Forecast / Applicant types 3 / Description | State governments |
| Forecast / Applicant types 4 / Id | 22 |
| Forecast / Applicant types 4 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 5 / Id | 07 |
| Forecast / Applicant types 5 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 6 / Id | 11 |
| Forecast / Applicant types 6 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 7 / Id | 12 |
| Forecast / Applicant types 7 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 8 / Id | 13 |
| Forecast / Applicant types 8 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 9 / Id | 20 |
| Forecast / Applicant types 9 / Description | Private institutions of higher education |
| Forecast / Applicant types 10 / Id | 06 |
| Forecast / Applicant types 10 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 11 / Id | 01 |
| Forecast / Applicant types 11 / Description | County governments |
| Forecast / Applicant types 12 / Id | 08 |
| Forecast / Applicant types 12 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 13 / Id | 05 |
| Forecast / Applicant types 13 / Description | Independent school districts |
| Forecast / Applicant types 14 / Id | 23 |
| Forecast / Applicant types 14 / Description | Small businesses |
| Forecast / Applicant types 15 / Id | 25 |
| Forecast / Applicant types 15 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-12-00-00-00 |
| Forecast / Est application response date str | 2026-02-10-00-00-00 |
| Forecast / Est award date str | 2026-11-01-00-00-00 |
| Forecast / Est project start date str | 2026-12-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-09-33-48 |
| Cfdas 1 / Id | 430761 |
| Cfdas 1 / Opportunity id | 360404 |
| Cfdas 1 / Revision | 1 |
| Cfdas 1 / Cfda number | 93.853 |
| Cfdas 1 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; opportunityNumber; sendEmail; modComments; createTimeStamp |
Forecast changes
revision
version
sendEmail
archiveDate
modComments
| Id | 360404 |
| Revision | 3 |
| Opportunity number | PAR-27-065 |
| Opportunity title | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Modified comments | Updated details to match current NOFO. |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Synopsis / Opportunity id | 360404 |
| Synopsis / Version | 1 |
| Synopsis / Agency code | HHS-NIH11 |
| Synopsis / Agency name | National Institutes of Health |
| Synopsis / Agency phone | 301-402-2541 |
| Synopsis / Agency address desc | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Synopsis / Agency details / Code | NIH |
| Synopsis / Agency details / Seed | HHS-NIH11 |
| Synopsis / Agency details / Agency name | National Institutes of Health |
| Synopsis / Agency details / Agency code | HHS-NIH11 |
| Synopsis / Agency details / Top agency code | HHS |
| Synopsis / Top agency details / Code | HHS |
| Synopsis / Top agency details / Seed | HHS |
| Synopsis / Top agency details / Agency name | Department of Health and Human Services |
| Synopsis / Top agency details / Agency code | HHS |
| Synopsis / Top agency details / Top agency code | HHS |
| Synopsis / Agency contact phone | 301-402-2541 |
| Synopsis / Agency contact name | National Institutes of Health |
| Synopsis / Agency contact desc | Exploratory_Efficacy_Trials@ninds.nih.gov Exploratory_Efficacy_Trials@ninds.nih.gov |
| Synopsis / Agency contact email | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Synopsis / Agency contact email desc | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Synopsis / Synopsis desc | This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials. |
| Synopsis / Response date | Mar 09, 2029 12:00:00 AM EST |
| Synopsis / Posting date | Aug 31, 2026 12:00:00 AM EDT |
| Synopsis / Archive date | May 08, 2029 12:00:00 AM EDT |
| Synopsis / Cost sharing | No |
| Synopsis / Award ceiling | none |
| Synopsis / Award floor | none |
| Synopsis / Applicant eligibility desc | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors. |
| Synopsis / Create time stamp | Aug 31, 2026 10:35:11 AM EDT |
| Synopsis / Created date | Aug 31, 2026 10:35:01 AM EDT |
| Synopsis / Last updated date | Aug 31, 2026 10:35:01 AM EDT |
| Synopsis / Applicant types 1 / Id | 07 |
| Synopsis / Applicant types 1 / Description | Native American tribal governments (Federally recognized) |
| Synopsis / Applicant types 2 / Id | 08 |
| Synopsis / Applicant types 2 / Description | Public housing authorities/Indian housing authorities |
| Synopsis / Applicant types 3 / Id | 00 |
| Synopsis / Applicant types 3 / Description | State governments |
| Synopsis / Applicant types 4 / Id | 04 |
| Synopsis / Applicant types 4 / Description | Special district governments |
| Synopsis / Applicant types 5 / Id | 22 |
| Synopsis / Applicant types 5 / Description | For profit organizations other than small businesses |
| Synopsis / Applicant types 6 / Id | 11 |
| Synopsis / Applicant types 6 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Synopsis / Applicant types 7 / Id | 02 |
| Synopsis / Applicant types 7 / Description | City or township governments |
| Synopsis / Applicant types 8 / Id | 23 |
| Synopsis / Applicant types 8 / Description | Small businesses |
| Synopsis / Applicant types 9 / Id | 25 |
| Synopsis / Applicant types 9 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Synopsis / Applicant types 10 / Id | 01 |
| Synopsis / Applicant types 10 / Description | County governments |
| Synopsis / Applicant types 11 / Id | 06 |
| Synopsis / Applicant types 11 / Description | Public and State controlled institutions of higher education |
| Synopsis / Applicant types 12 / Id | 12 |
| Synopsis / Applicant types 12 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Applicant types 13 / Id | 05 |
| Synopsis / Applicant types 13 / Description | Independent school districts |
| Synopsis / Applicant types 14 / Id | 20 |
| Synopsis / Applicant types 14 / Description | Private institutions of higher education |
| Synopsis / Applicant types 15 / Id | 13 |
| Synopsis / Applicant types 15 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Funding instruments 1 / Id | CA |
| Synopsis / Funding instruments 1 / Description | Cooperative Agreement |
| Synopsis / Funding activity categories 1 / Id | HL |
| Synopsis / Funding activity categories 1 / Description | Health |
| Synopsis / Response date str | 2029-03-09-00-00-00 |
| Synopsis / Posting date str | 2026-08-31-00-00-00 |
| Synopsis / Archive date str | 2029-05-08-00-00-00 |
| Synopsis / Create time stamp str | 2026-08-31-10-35-11 |
| Agency details / Code | NIH |
| Agency details / Seed | HHS-NIH11 |
| Agency details / Agency name | National Institutes of Health |
| Agency details / Agency code | HHS-NIH11 |
| Agency details / Top agency code | HHS |
| Top agency details / Code | HHS |
| Top agency details / Seed | HHS |
| Top agency details / Agency name | Department of Health and Human Services |
| Top agency details / Agency code | HHS |
| Top agency details / Top agency code | HHS |
| Forecast / Opportunity id | 360404 |
| Forecast / Version | 3 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Archive date | Aug 30, 2026 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on exploratory and efficacy clinical trials that address questions within the mission and research interests of the NINDS and may evaluate drugs, biologics, and devices, as well as surgical, behavioral and rehabilitation therapies. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into the mission and research interests of the NINDS, found at the NINDS website (https://www.ninds.nih.gov/), are encouraged to begin to consider applying for this new NOFO. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Jeremy Brown, MD |
| Forecast / Agency contact phone | Please contact via e-mail. |
| Forecast / Agency contact email | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency contact email desc | Exploratory_Efficacy_Trials@ninds.nih.gov |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Nov 12, 2025 12:00:00 AM EST |
| Forecast / Est application response date | Feb 10, 2026 12:00:00 AM EST |
| Forecast / Est award date | Nov 01, 2026 12:00:00 AM EDT |
| Forecast / Est project start date | Dec 01, 2026 12:00:00 AM EST |
| Forecast / Fiscal year | 2026 |
| Forecast / Mod comments | Updated Archive Date |
| Forecast / Create time stamp | Aug 31, 2026 10:35:11 AM EDT |
| Forecast / Created date | Aug 28, 2025 03:37:53 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 10:35:11 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 07 |
| Forecast / Applicant types 1 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 2 / Id | 08 |
| Forecast / Applicant types 2 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 3 / Id | 00 |
| Forecast / Applicant types 3 / Description | State governments |
| Forecast / Applicant types 4 / Id | 04 |
| Forecast / Applicant types 4 / Description | Special district governments |
| Forecast / Applicant types 5 / Id | 22 |
| Forecast / Applicant types 5 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 6 / Id | 11 |
| Forecast / Applicant types 6 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 7 / Id | 02 |
| Forecast / Applicant types 7 / Description | City or township governments |
| Forecast / Applicant types 8 / Id | 23 |
| Forecast / Applicant types 8 / Description | Small businesses |
| Forecast / Applicant types 9 / Id | 25 |
| Forecast / Applicant types 9 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 10 / Id | 01 |
| Forecast / Applicant types 10 / Description | County governments |
| Forecast / Applicant types 11 / Id | 06 |
| Forecast / Applicant types 11 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 12 / Id | 12 |
| Forecast / Applicant types 12 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 13 / Id | 05 |
| Forecast / Applicant types 13 / Description | Independent school districts |
| Forecast / Applicant types 14 / Id | 20 |
| Forecast / Applicant types 14 / Description | Private institutions of higher education |
| Forecast / Applicant types 15 / Id | 13 |
| Forecast / Applicant types 15 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Archive date str | 2026-08-30-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-12-00-00-00 |
| Forecast / Est application response date str | 2026-02-10-00-00-00 |
| Forecast / Est award date str | 2026-11-01-00-00-00 |
| Forecast / Est project start date str | 2026-12-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-10-35-11 |
| Synopsis attachment folders 1 / Id | 81210 |
| Synopsis attachment folders 1 / Opportunity id | 360404 |
| Synopsis attachment folders 1 / Folder type | Full Announcement |
| Synopsis attachment folders 1 / Folder name | Full Announcement |
| Synopsis attachment folders 1 / Zip lob size | 40405 |
| Synopsis attachment folders 1 / Created date | Aug 31, 2026 10:35:11 AM EDT |
| Synopsis attachment folders 1 / Last updated date | Aug 31, 2026 10:35:11 AM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Id | 354876 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Opportunity id | 360404 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Mime type | text/html;charset=UTF-8 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File name | PAR-27-065-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File description | PAR-27-065-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File lob size | 165191 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Created date | Aug 31, 2026 10:35:11 AM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Synopsis att folder id | 81210 |
| Synopsis document urls | Not specified |
| Syn att change comments | Not specified |
| Cfdas 1 / Id | 430761 |
| Cfdas 1 / Opportunity id | 360404 |
| Cfdas 1 / Cfda number | 93.853 |
| Cfdas 1 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Opportunity pkgs 1 / Id | 294087 |
| Opportunity pkgs 1 / Topportunity id | 360404 |
| Opportunity pkgs 1 / Family id | 14 |
| Opportunity pkgs 1 / Dialect | XFDL2.2 |
| Opportunity pkgs 1 / Opportunity number | PAR-27-065 |
| Opportunity pkgs 1 / Opportunity title | NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Opportunity pkgs 1 / Cfda number | 93.853 |
| Opportunity pkgs 1 / Opening date | 2026-10-09 |
| Opportunity pkgs 1 / Closing date | 2029-03-09 |
| Opportunity pkgs 1 / Owning agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Code | NIH |
| Opportunity pkgs 1 / Agency details / Seed | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Agency name | National Institutes of Health |
| Opportunity pkgs 1 / Agency details / Agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Code | HHS |
| Opportunity pkgs 1 / Top agency details / Seed | HHS |
| Opportunity pkgs 1 / Top agency details / Agency name | Department of Health and Human Services |
| Opportunity pkgs 1 / Top agency details / Agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Opportunity pkgs 1 / Contact info | eRA Service Desk https://www.era.nih.gov/need-help |
| Opportunity pkgs 1 / Grace period | 60 |
| Opportunity pkgs 1 / Competition id | FORMS-I |
| Opportunity pkgs 1 / Competition title | Use for due date on or after January 25, 2025. |
| Opportunity pkgs 1 / Electronic required | Y |
| Opportunity pkgs 1 / Expected application count | 100 |
| Opportunity pkgs 1 / Open to applicant type | 1 |
| Opportunity pkgs 1 / Is multi project | N |
| Opportunity pkgs 1 / Extension | |
| Opportunity pkgs 1 / Mimetype | application/pdf |
| Opportunity pkgs 1 / Last update | Aug 31, 2026 10:39:43 AM EDT |
| Opportunity pkgs 1 / Workspace compatible flag | Y |
| Opportunity pkgs 1 / Package id | PKG00294087 |
| Opportunity pkgs 1 / Opening date str | 2026-10-09-00-00-00 |
| Opportunity pkgs 1 / Closing date str | 2029-03-09-00-00-00 |
| Closed opportunity pkgs | Not specified |
| Original due date | Mar 09, 2029 12:00:00 AM EST |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; sendEmail; archiveDate; modComments |
| Error messages | Not specified |
| Syn post date in past | Yes |
| Doc type | synopsis |
| Forecast hist count | 2 |
| Synopsis hist count | 0 |
| Assist compatible | No |
| Assist url | Not specified |
| Related opps | Not specified |
| Ost | POSTED |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | Exploratory_Efficacy_Trials@ninds.nih.gov Exploratory_Efficacy_Trials@ninds.nih.gov |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.853 | FORMS-I | Use for due date on or after January 25, 2025. | PKG00294087 | 2026-10-09 | 2029-03-09 | View |
Package 1
Instructions
PKG00294120-instructions.pdf
Mandatory forms
RR_SF424_5_0-V5.0.pdf
PHS398_CoverPageSupplement_5_0-V5.0.pdf
RR_OtherProjectInfo_1_4-V1.4.pdf
PerformanceSite_4_0-V4.0.pdf
RR_KeyPersonExpanded_4_0-V4.0.pdf
RR_Budget10_3_0-V3.0.pdf
PHS398_ResearchPlan_5_0-V5.0.pdf
PHSHumanSubjectsAndClinicalTrialsInfo_3_0-V3.0.pdf
Optional forms
RR_SubawardBudget10_30_3_0-V3.0.pdf
PHS_AssignmentRequestForm_4_0-V4.0.pdf
