Opportunity ID: 360606
General Information
| Funding Opportunity Number | RFA-CA-27-005 |
| Funding Opportunity Title | Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required) |
| Agency | National Institutes of Health |
| Document Type | synopsis |
| Version | 1 |
| Opportunity Category | Discretionary |
| Opportunity Category Explanation | Not specified |
| Funding Instrument Type | Cooperative Agreement |
| Category of Funding Activity | Health |
| Category Explanation | Not specified |
| Expected Number of Awards | 4 |
| Cost Sharing or Matching Requirement | No |
| Posted Date | Aug 31, 2026 12:00:00 AM EDT |
| Last Updated Date | Aug 31, 2026 09:35:48 AM EDT |
| Original Closing Date | Oct 01, 2026 12:00:00 AM EDT |
| Original Closing Date Notes | Not specified |
| Current Closing Date | Oct 01, 2026 12:00:00 AM EDT |
| Current Closing Date Notes | Not specified |
| Estimated Synopsis Date | Not specified |
| Estimated Application Due Date | Not specified |
| Estimated Award Date | Not specified |
| Estimated Project Start Date | Not specified |
| Archive Date | Nov 30, 2026 12:00:00 AM EST |
| Estimated Total Program Funding | 4,400,000 |
| Award Ceiling | 700,000 |
| Award Floor | none |
Assistance Listings
- 93.394 — Cancer Detection and Diagnosis Research
- 93.395 — Cancer Treatment Research
Eligibility
| Eligible Applicants | Public housing authorities/Indian housing authorities; City or township governments; State governments; Public and State controlled institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Independent school districts; Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; For profit organizations other than small businesses |
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.
Additional Information
| Contact | National Institutes of Health |
| Contact Information | NCI GTN Program National Cancer Institute (NCI) GTN-contacts@nih.gov |
| GTN-contacts@nih.gov | |
| Email Description | National Cancer Institute (NCI) |
| Phone | 301-402-2541 |
Additional information
Version History
Version history
| Opp hist id / Opportunity id | 360606 |
| Opp hist id / Revision | 0 |
| Opportunity id | 360606 |
| Revision | 0 |
| Opportunity number | RFA-CA-25-033 |
| Opportunity title | Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Forecast / Opp hist id / Opportunity id | 360606 |
| Forecast / Opp hist id / Revision | 0 |
| Forecast / Opportunity id | 360606 |
| Forecast / Revision | 0 |
| Forecast / Version | 1 |
| Forecast / Posting date | Sep 17, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms. To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Suzanne Forry, Ph.D. |
| Forecast / Agency contact phone | 240-276-5922 |
| Forecast / Agency contact email | forryscs@mail.nih.gov |
| Forecast / Agency contact email desc | National Cancer Institute (NCI) |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations; |
| Forecast / Est synopsis posting date | Nov 28, 2025 12:00:00 AM EST |
| Forecast / Est application response date | May 27, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Est project start date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Fiscal year | 2027 |
| Forecast / Create time stamp | Sep 17, 2025 10:19:53 AM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 09:30:45 AM EDT |
| Forecast / Created date | Sep 17, 2025 10:19:53 AM EDT |
| Forecast / Last updated date | Sep 17, 2025 10:19:53 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 12 |
| Forecast / Applicant types 1 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 2 / Id | 07 |
| Forecast / Applicant types 2 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 3 / Id | 01 |
| Forecast / Applicant types 3 / Description | County governments |
| Forecast / Applicant types 4 / Id | 06 |
| Forecast / Applicant types 4 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 5 / Id | 00 |
| Forecast / Applicant types 5 / Description | State governments |
| Forecast / Applicant types 6 / Id | 02 |
| Forecast / Applicant types 6 / Description | City or township governments |
| Forecast / Applicant types 7 / Id | 20 |
| Forecast / Applicant types 7 / Description | Private institutions of higher education |
| Forecast / Applicant types 8 / Id | 11 |
| Forecast / Applicant types 8 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 9 / Id | 05 |
| Forecast / Applicant types 9 / Description | Independent school districts |
| Forecast / Applicant types 10 / Id | 25 |
| Forecast / Applicant types 10 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 11 / Id | 13 |
| Forecast / Applicant types 11 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 12 / Id | 22 |
| Forecast / Applicant types 12 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 13 / Id | 08 |
| Forecast / Applicant types 13 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 14 / Id | 23 |
| Forecast / Applicant types 14 / Description | Small businesses |
| Forecast / Applicant types 15 / Id | 04 |
| Forecast / Applicant types 15 / Description | Special district governments |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-09-17-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-28-00-00-00 |
| Forecast / Est application response date str | 2026-05-27-00-00-00 |
| Forecast / Est award date str | 2027-03-05-00-00-00 |
| Forecast / Est project start date str | 2027-03-05-00-00-00 |
| Forecast / Create time stamp str | 2025-09-17-10-19-53 |
| Cfdas 1 / Id | 431125 |
| Cfdas 1 / Opportunity id | 360606 |
| Cfdas 1 / Revision | 1 |
| Cfdas 1 / Cfda number | 93.394 |
| Cfdas 1 / Program title | Cancer Detection and Diagnosis Research |
| Cfdas 2 / Id | 431126 |
| Cfdas 2 / Opportunity id | 360606 |
| Cfdas 2 / Revision | 1 |
| Cfdas 2 / Cfda number | 93.395 |
| Cfdas 2 / Program title | Cancer Treatment Research |
| Synopsis modified fields | Not specified |
| Forecast modified fields | Not specified |
| Opp hist id / Opportunity id | 360606 |
| Opp hist id / Revision | 2 |
| Opportunity id | 360606 |
| Revision | 2 |
| Opportunity number | RFA-CA-27-005 |
| Opportunity title | Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Modified comments | Updated details to match current NOFO. |
| Forecast / Opp hist id / Opportunity id | 360606 |
| Forecast / Opp hist id / Revision | 2 |
| Forecast / Opportunity id | 360606 |
| Forecast / Revision | 2 |
| Forecast / Version | 2 |
| Forecast / Posting date | Sep 17, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms. To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Suzanne Forry, Ph.D. |
| Forecast / Agency contact phone | 240-276-5922 |
| Forecast / Agency contact email | forryscs@mail.nih.gov |
| Forecast / Agency contact email desc | National Cancer Institute (NCI) |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations; |
| Forecast / Est synopsis posting date | Nov 28, 2025 12:00:00 AM EST |
| Forecast / Est application response date | May 27, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Est project start date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Updated details to match current NOFO. |
| Forecast / Create time stamp | Aug 31, 2026 09:30:45 AM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 09:35:48 AM EDT |
| Forecast / Created date | Sep 17, 2025 10:19:53 AM EDT |
| Forecast / Last updated date | Aug 31, 2026 09:30:45 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 12 |
| Forecast / Applicant types 1 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 2 / Id | 07 |
| Forecast / Applicant types 2 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 3 / Id | 01 |
| Forecast / Applicant types 3 / Description | County governments |
| Forecast / Applicant types 4 / Id | 06 |
| Forecast / Applicant types 4 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 5 / Id | 00 |
| Forecast / Applicant types 5 / Description | State governments |
| Forecast / Applicant types 6 / Id | 02 |
| Forecast / Applicant types 6 / Description | City or township governments |
| Forecast / Applicant types 7 / Id | 20 |
| Forecast / Applicant types 7 / Description | Private institutions of higher education |
| Forecast / Applicant types 8 / Id | 11 |
| Forecast / Applicant types 8 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 9 / Id | 05 |
| Forecast / Applicant types 9 / Description | Independent school districts |
| Forecast / Applicant types 10 / Id | 25 |
| Forecast / Applicant types 10 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 11 / Id | 13 |
| Forecast / Applicant types 11 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 12 / Id | 22 |
| Forecast / Applicant types 12 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 13 / Id | 08 |
| Forecast / Applicant types 13 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 14 / Id | 23 |
| Forecast / Applicant types 14 / Description | Small businesses |
| Forecast / Applicant types 15 / Id | 04 |
| Forecast / Applicant types 15 / Description | Special district governments |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-09-17-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-28-00-00-00 |
| Forecast / Est application response date str | 2026-05-27-00-00-00 |
| Forecast / Est award date str | 2027-03-05-00-00-00 |
| Forecast / Est project start date str | 2027-03-05-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-09-30-45 |
| Cfdas 1 / Id | 431125 |
| Cfdas 1 / Opportunity id | 360606 |
| Cfdas 1 / Revision | 1 |
| Cfdas 1 / Cfda number | 93.394 |
| Cfdas 1 / Program title | Cancer Detection and Diagnosis Research |
| Cfdas 2 / Id | 431126 |
| Cfdas 2 / Opportunity id | 360606 |
| Cfdas 2 / Revision | 1 |
| Cfdas 2 / Cfda number | 93.395 |
| Cfdas 2 / Program title | Cancer Treatment Research |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; opportunityNumber; opportunityTitle; sendEmail; modComments; createTimeStamp |
Forecast changes
revision
version
sendEmail
archiveDate
modComments
| Id | 360606 |
| Revision | 3 |
| Opportunity number | RFA-CA-27-005 |
| Opportunity title | Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required) |
| Owning agency code | HHS-NIH11 |
| Modified comments | Updated details to match current NOFO. |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Synopsis / Opportunity id | 360606 |
| Synopsis / Version | 1 |
| Synopsis / Agency code | HHS-NIH11 |
| Synopsis / Agency name | National Institutes of Health |
| Synopsis / Agency phone | 301-402-2541 |
| Synopsis / Agency address desc | National Cancer Institute (NCI) |
| Synopsis / Agency details / Code | NIH |
| Synopsis / Agency details / Seed | HHS-NIH11 |
| Synopsis / Agency details / Agency name | National Institutes of Health |
| Synopsis / Agency details / Agency code | HHS-NIH11 |
| Synopsis / Agency details / Top agency code | HHS |
| Synopsis / Top agency details / Code | HHS |
| Synopsis / Top agency details / Seed | HHS |
| Synopsis / Top agency details / Agency name | Department of Health and Human Services |
| Synopsis / Top agency details / Agency code | HHS |
| Synopsis / Top agency details / Top agency code | HHS |
| Synopsis / Agency contact phone | 301-402-2541 |
| Synopsis / Agency contact name | National Institutes of Health |
| Synopsis / Agency contact desc | NCI GTN Program National Cancer Institute (NCI) GTN-contacts@nih.gov |
| Synopsis / Agency contact email | GTN-contacts@nih.gov |
| Synopsis / Agency contact email desc | National Cancer Institute (NCI) |
| Synopsis / Synopsis desc | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process. |
| Synopsis / Response date | Oct 01, 2026 12:00:00 AM EDT |
| Synopsis / Posting date | Aug 31, 2026 12:00:00 AM EDT |
| Synopsis / Archive date | Nov 30, 2026 12:00:00 AM EST |
| Synopsis / Cost sharing | No |
| Synopsis / Number of awards | 4 |
| Synopsis / Estimated funding | 4400000 |
| Synopsis / Estimated funding formatted | 4,400,000 |
| Synopsis / Award ceiling | 700000 |
| Synopsis / Award ceiling formatted | 700,000 |
| Synopsis / Award floor | none |
| Synopsis / Applicant eligibility desc | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
| Synopsis / Create time stamp | Aug 31, 2026 09:35:58 AM EDT |
| Synopsis / Created date | Aug 31, 2026 09:35:48 AM EDT |
| Synopsis / Last updated date | Aug 31, 2026 09:35:48 AM EDT |
| Synopsis / Applicant types 1 / Id | 08 |
| Synopsis / Applicant types 1 / Description | Public housing authorities/Indian housing authorities |
| Synopsis / Applicant types 2 / Id | 02 |
| Synopsis / Applicant types 2 / Description | City or township governments |
| Synopsis / Applicant types 3 / Id | 00 |
| Synopsis / Applicant types 3 / Description | State governments |
| Synopsis / Applicant types 4 / Id | 06 |
| Synopsis / Applicant types 4 / Description | Public and State controlled institutions of higher education |
| Synopsis / Applicant types 5 / Id | 11 |
| Synopsis / Applicant types 5 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Synopsis / Applicant types 6 / Id | 13 |
| Synopsis / Applicant types 6 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Applicant types 7 / Id | 23 |
| Synopsis / Applicant types 7 / Description | Small businesses |
| Synopsis / Applicant types 8 / Id | 05 |
| Synopsis / Applicant types 8 / Description | Independent school districts |
| Synopsis / Applicant types 9 / Id | 20 |
| Synopsis / Applicant types 9 / Description | Private institutions of higher education |
| Synopsis / Applicant types 10 / Id | 25 |
| Synopsis / Applicant types 10 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Synopsis / Applicant types 11 / Id | 01 |
| Synopsis / Applicant types 11 / Description | County governments |
| Synopsis / Applicant types 12 / Id | 07 |
| Synopsis / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Synopsis / Applicant types 13 / Id | 12 |
| Synopsis / Applicant types 13 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Applicant types 14 / Id | 04 |
| Synopsis / Applicant types 14 / Description | Special district governments |
| Synopsis / Applicant types 15 / Id | 22 |
| Synopsis / Applicant types 15 / Description | For profit organizations other than small businesses |
| Synopsis / Funding instruments 1 / Id | CA |
| Synopsis / Funding instruments 1 / Description | Cooperative Agreement |
| Synopsis / Funding activity categories 1 / Id | HL |
| Synopsis / Funding activity categories 1 / Description | Health |
| Synopsis / Response date str | 2026-10-01-00-00-00 |
| Synopsis / Posting date str | 2026-08-31-00-00-00 |
| Synopsis / Archive date str | 2026-11-30-00-00-00 |
| Synopsis / Create time stamp str | 2026-08-31-09-35-58 |
| Agency details / Code | NIH |
| Agency details / Seed | HHS-NIH11 |
| Agency details / Agency name | National Institutes of Health |
| Agency details / Agency code | HHS-NIH11 |
| Agency details / Top agency code | HHS |
| Top agency details / Code | HHS |
| Top agency details / Seed | HHS |
| Top agency details / Agency name | Department of Health and Human Services |
| Top agency details / Agency code | HHS |
| Top agency details / Top agency code | HHS |
| Forecast / Opportunity id | 360606 |
| Forecast / Version | 3 |
| Forecast / Posting date | Sep 17, 2025 12:00:00 AM EDT |
| Forecast / Archive date | Aug 30, 2026 12:00:00 AM EDT |
| Forecast / Forecast desc | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms. To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Suzanne Forry, Ph.D. |
| Forecast / Agency contact phone | 240-276-5922 |
| Forecast / Agency contact email | forryscs@mail.nih.gov |
| Forecast / Agency contact email desc | National Cancer Institute (NCI) |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations; |
| Forecast / Est synopsis posting date | Nov 28, 2025 12:00:00 AM EST |
| Forecast / Est application response date | May 27, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Est project start date | Mar 05, 2027 12:00:00 AM EST |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Updated Archive Date |
| Forecast / Create time stamp | Aug 31, 2026 09:35:58 AM EDT |
| Forecast / Created date | Sep 17, 2025 10:19:53 AM EDT |
| Forecast / Last updated date | Aug 31, 2026 09:35:58 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 08 |
| Forecast / Applicant types 1 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 2 / Id | 02 |
| Forecast / Applicant types 2 / Description | City or township governments |
| Forecast / Applicant types 3 / Id | 00 |
| Forecast / Applicant types 3 / Description | State governments |
| Forecast / Applicant types 4 / Id | 06 |
| Forecast / Applicant types 4 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 5 / Id | 11 |
| Forecast / Applicant types 5 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 6 / Id | 13 |
| Forecast / Applicant types 6 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 7 / Id | 23 |
| Forecast / Applicant types 7 / Description | Small businesses |
| Forecast / Applicant types 8 / Id | 05 |
| Forecast / Applicant types 8 / Description | Independent school districts |
| Forecast / Applicant types 9 / Id | 20 |
| Forecast / Applicant types 9 / Description | Private institutions of higher education |
| Forecast / Applicant types 10 / Id | 25 |
| Forecast / Applicant types 10 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 11 / Id | 01 |
| Forecast / Applicant types 11 / Description | County governments |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 12 |
| Forecast / Applicant types 13 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 14 / Id | 04 |
| Forecast / Applicant types 14 / Description | Special district governments |
| Forecast / Applicant types 15 / Id | 22 |
| Forecast / Applicant types 15 / Description | For profit organizations other than small businesses |
| Forecast / Funding instruments 1 / Id | CA |
| Forecast / Funding instruments 1 / Description | Cooperative Agreement |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-09-17-00-00-00 |
| Forecast / Archive date str | 2026-08-30-00-00-00 |
| Forecast / Est synopsis posting date str | 2025-11-28-00-00-00 |
| Forecast / Est application response date str | 2026-05-27-00-00-00 |
| Forecast / Est award date str | 2027-03-05-00-00-00 |
| Forecast / Est project start date str | 2027-03-05-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-09-35-58 |
| Synopsis attachment folders 1 / Id | 81205 |
| Synopsis attachment folders 1 / Opportunity id | 360606 |
| Synopsis attachment folders 1 / Folder type | Full Announcement |
| Synopsis attachment folders 1 / Folder name | Full Announcement |
| Synopsis attachment folders 1 / Zip lob size | 51836 |
| Synopsis attachment folders 1 / Created date | Aug 31, 2026 09:35:57 AM EDT |
| Synopsis attachment folders 1 / Last updated date | Aug 31, 2026 09:35:58 AM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Id | 354867 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Opportunity id | 360606 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Mime type | text/html;charset=UTF-8 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File name | RFA-CA-27-005-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File description | RFA-CA-27-005-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File lob size | 223846 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Created date | Aug 31, 2026 09:35:58 AM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Synopsis att folder id | 81205 |
| Synopsis document urls | Not specified |
| Syn att change comments | Not specified |
| Cfdas 1 / Id | 431125 |
| Cfdas 1 / Opportunity id | 360606 |
| Cfdas 1 / Cfda number | 93.394 |
| Cfdas 1 / Program title | Cancer Detection and Diagnosis Research |
| Cfdas 2 / Id | 431126 |
| Cfdas 2 / Opportunity id | 360606 |
| Cfdas 2 / Cfda number | 93.395 |
| Cfdas 2 / Program title | Cancer Treatment Research |
| Opportunity pkgs 1 / Id | 294082 |
| Opportunity pkgs 1 / Topportunity id | 360606 |
| Opportunity pkgs 1 / Family id | 14 |
| Opportunity pkgs 1 / Dialect | XFDL2.2 |
| Opportunity pkgs 1 / Opportunity number | RFA-CA-27-005 |
| Opportunity pkgs 1 / Opportunity title | Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required) |
| Opportunity pkgs 1 / Cfda number | 93.394 |
| Opportunity pkgs 1 / Opening date | 2026-09-01 |
| Opportunity pkgs 1 / Closing date | 2026-10-01 |
| Opportunity pkgs 1 / Owning agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Code | NIH |
| Opportunity pkgs 1 / Agency details / Seed | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Agency name | National Institutes of Health |
| Opportunity pkgs 1 / Agency details / Agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Code | HHS |
| Opportunity pkgs 1 / Top agency details / Seed | HHS |
| Opportunity pkgs 1 / Top agency details / Agency name | Department of Health and Human Services |
| Opportunity pkgs 1 / Top agency details / Agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Program title | Cancer Detection and Diagnosis Research |
| Opportunity pkgs 1 / Contact info | eRA Service Desk https://www.era.nih.gov/need-help |
| Opportunity pkgs 1 / Grace period | 60 |
| Opportunity pkgs 1 / Competition id | FORMS-I |
| Opportunity pkgs 1 / Competition title | Use for due date on or after January 25, 2025. |
| Opportunity pkgs 1 / Electronic required | Y |
| Opportunity pkgs 1 / Expected application count | 100 |
| Opportunity pkgs 1 / Open to applicant type | 1 |
| Opportunity pkgs 1 / Is multi project | Y |
| Opportunity pkgs 1 / Extension | |
| Opportunity pkgs 1 / Mimetype | application/pdf |
| Opportunity pkgs 1 / Last update | Aug 31, 2026 09:36:16 AM EDT |
| Opportunity pkgs 1 / Agency download url | http://https://public.era.nih.gov/assist |
| Opportunity pkgs 1 / Workspace compatible flag | N |
| Opportunity pkgs 1 / Package id | PKG00294082 |
| Opportunity pkgs 1 / Opening date str | 2026-09-01-00-00-00 |
| Opportunity pkgs 1 / Closing date str | 2026-10-01-00-00-00 |
| Closed opportunity pkgs | Not specified |
| Original due date | Oct 01, 2026 12:00:00 AM EDT |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; sendEmail; archiveDate; modComments |
| Error messages | Not specified |
| Syn post date in past | Yes |
| Doc type | synopsis |
| Forecast hist count | 2 |
| Synopsis hist count | 0 |
| Assist compatible | No |
| Assist url | Not specified |
| Related opps | Not specified |
| Ost | POSTED |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NCI GTN Program National Cancer Institute (NCI) GTN-contacts@nih.gov |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.394 | FORMS-I | Use for due date on or after January 25, 2025. | PKG00294082 | 2026-09-01 | 2026-10-01 | View |
Package 1
Instructions
PKG00294099-instructions.pdf
Mandatory forms
RR_SF424_5_0-V5.0.pdf
PHS398_CoverPageSupplement_5_0-V5.0.pdf
RR_OtherProjectInfo_1_4-V1.4.pdf
PerformanceSite_4_0-V4.0.pdf
RR_KeyPersonExpanded_4_0-V4.0.pdf
PHS398_ResearchPlan_5_0-V5.0.pdf
PHSHumanSubjectsAndClinicalTrialsInfo_3_0-V3.0.pdf
RR_SF424_Multi_Project_Cover_4_0-V4.0.pdf
RR_MP_Budget_3_0-V3.0.pdf
Optional forms
PHS_Additional_IndirectCosts_2_0-V2.0.pdf
PHS_AssignmentRequestForm_4_0-V4.0.pdf
RR_MP_SubawardBudget_3_0-V3.0.pdf
