This grant offered by the NIAID Radiation/Nuclear Countermeasures Development Program supports research on understanding the impact of radiation on the endovascular network. The research aims to develop treatments and mitigators for radiation-induced endothelial cell and vascular dysfunction, with the ultimate goal of addressing multi-organ dysfunction and failure post-radiation exposure. Academic, industry, and government lab researchers can apply to advance the understanding of radiation injury in the vasculature and develop post-exposure treatments targeting the vascular endothelium. The end goal is FDA licensure for medical countermeasures in public health emergencies related to radiation/nuclear incidents. Deadline for application submission is Nov 10, 2016.
Opportunity ID: 286871
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-16-053 |
| Funding Opportunity Title: | Elucidation of Mechanisms of Radiation-Induced Endovascular Injury and Development of Treatments / Mitigators for Radiation-Induced Endothelial Cell and Vascular Dysfunction (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 02, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 10, 2016 |
| Current Closing Date for Applications: | Nov 10, 2016 |
| Archive Date: | Dec 11, 2016 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $350,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Independent school districts For profit organizations other than small businesses Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. The purpose of the Funding Opportunity Announcement (FOA) is to provide an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. This funding will also advance the development of post-exposure treatment approaches targeting the vascular endothelium, with the ultimate goal of licensure of candidate medical countermeasures by the Food and Drug Administration (FDA) for the radiation/nuclear public health emergency indication. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-16-053.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00226306 | Oct 10, 2016 | Nov 10, 2016 | View |
Package 1
Mandatory forms
286871 RR_SF424_2_0-2.0.pdf
286871 PHS398_CoverPageSupplement_3_0-3.0.pdf
286871 RR_OtherProjectInfo_1_3-1.3.pdf
286871 PerformanceSite_2_0-2.0.pdf
286871 RR_KeyPersonExpanded_2_0-2.0.pdf
286871 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
286871 RR_Budget_1_3-1.3.pdf
286871 RR_SubawardBudget30_1_3-1.3.pdf
286871 PHS398_ModularBudget_1_2-1.2.pdf
286871 PHS_Inclusion_Enrollment_Report-1.0.pdf
286871 PHS_AssignmentRequestForm-1.0.pdf
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